98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978488 | PMC |
http://dx.doi.org/10.1038/s41375-025-02534-5 | DOI Listing |
J Chromatogr B Analyt Technol Biomed Life Sci
May 2025
Department of Social and Environmental Medicine, Saga University. 5-1-1 Nabeshima, Saga 849-8501, Japan. Electronic address:
Glucocorticoids, regulators of energy metabolism and immune responses, are known biomarkers of stress response and disease. Downscaling the required sample volumes facilitates large-scale studies and accelerates the generation of valid results. To meet this expectation, we modified our LC-MS/MS method using 100 μL of urine to that using 20 μL, following the same steps as in the original protocol with the addition of cortisone-d8 as an internal standard.
View Article and Find Full Text PDFEndocrine
June 2025
Department of Human Pathology of Childhood and Adulthood "Gaetano Barresi", University of Messina, Messina, Italy.
Purpose: Pasireotide is the first pituitary-directed approved therapy for Cushing's disease (CD), effective in reducing 24 h urine free cortisol (UFC) > 50% in more than half of patients, with beneficial effects and with a relatively high incidence of hyperglycemia. The aim of this study was to evaluate efficacy and safety of long-term treatment with pasireotide (PAS) in CD patients, also according to gender.
Methods: We retrospectively evaluated 19 consecutive CD patients (13F; age at diagnosis: 34.
J Clin Pathol
July 2025
National Clinical Research Center for Kidney Diseases, Jinling Hospital, Nanjing Medical University, Nanjing, China
Aims: Light chain proximal tubulopathy (LCPT) is a rare complication of paraprotein-related diseases. We report a case series to present the clinicopathological characteristics and outcomes of LCPT.
Methods: A multicentre retrospective case series of 47 patients with LCPT, consisting of 36 crystalline, three non-crystalline, and eight mixed LCPTs, was studied between January 2007 and December 2023.
Psychoneuroendocrinology
February 2025
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, United States. Electronic address:
Hyperactive and hyperreactive HPA axis functions are frequently reported in depressive disorders, particularly in major depression. However, research into HPA axis function in women with premenstrual dysphoric disorder (PMDD), which is also classified as a depressive disorder, has shown inconsistent results. This study aimed to characterize the HPA axis in women with PMDD using the combined dexamethasone suppression and CRH stimulation (Dex/CRH) test, alongside measurements of 24-hour urine free cortisol (UFC).
View Article and Find Full Text PDF