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Introduction: Animal vehicle collisions (AVCs) are a global safety concern, requiring analysis and predictive models for understanding and mitigation. Police crash report data are one of the main sources of AVC data globally. However, they are prone to reporting policy change and other inconsistencies, particularly in rural areas, hindering the development of predictive models. Through development of a robust approach for data cleaning, quality control, feature selection, and contribution level identification, this study proposes a pipeline to address this shortcoming.
Method: North Dakota crash data set is used as a case study due to high rates on AVC in this rural region and its diverse wildlife ecosystem. Theil's U association index, and chi-square tests were implemented in the pipeline to evaluate the proposed pipeline effectiveness. The pipeline detects and removes skewed proportion samples, while addressing data collection inconsistency, low variance, and duplicated features.
Results: Pipeline imposed 3.5% sample size and 88.9% feature size reduction on the original crash data over 20 years. Observation on the modified dataset revealed year, day, and driver features had the lowest while hour, county, and speed limit had the highest statistical contribution to the AVC. Light, hour, and month were lumped in daily solar cycle and represented as a single temporal feature that can be used effectively to develop predictive model. Finally, presented pipeline increased spatiotemporal integrity while reducing the runtime by 92.46% for the association analysis.
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http://dx.doi.org/10.1016/j.jsr.2024.12.002 | DOI Listing |
ACS Biomater Sci Eng
September 2025
Departamento de Genética, Evolução, Microbiologia e Immunologia, Instituto de Biologia, Universidade Estadual de Campinas - UNICAMP, Campinas, São Paulo 13083-862, Brazil.
Violacein exhibits antitumor activity, indicating potential for future clinical application. However, an efficient delivery system is required for the clinical use of this hydrophobic compound. Effective delivery systems can enhance the solubility and bioavailability of hydrophobic compounds like violacein, facilitating its clinical application for antitumor therapy.
View Article and Find Full Text PDFRadiat Environ Biophys
September 2025
Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Sodium orthovanadate (vanadate), a potent inhibitor of p53, has been shown in earlier work to alleviate total-body irradiation (TBI)-induced hematopoietic syndrome. However, as p53 plays a crucial role in normal spermatogenesis, its suppression may raise concerns about potential adverse effects on male reproductive function. In this study, we investigated whether vanadate exacerbates impairment of male fertility when administered for hematopoietic protection under TBI conditions.
View Article and Find Full Text PDFTransl Vis Sci Technol
September 2025
Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Purpose: The purinergic receptor P2X4 is critical to transduction of ocular pain. The aim of this study was to investigate the therapeutic potential of the P2X4 receptor antagonist BAY-776 in alleviating chronic ocular pain.
Methods: Chronic ocular pain was induced in male rats (8-9 weeks old; n = 12 per group) via double lacrimal gland removal (DLGR).
One Health
December 2025
U.S. Geological Survey, Eastern Ecological Science Center, Laurel, MD 20708, USA.
With the continued spread of highly pathogenic avian influenza (HPAI), understanding the complex dynamics of virus transfer at the wild - agriculture interface is paramount. Spillover events (i.e.
View Article and Find Full Text PDF3 Biotech
October 2025
Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, 110062 India.
Cyclophosphamide (CP), an anti-cancer drug, causes oxidative stress, inflammation, apoptosis and fibrosis in liver. Verbenone (VRB), a bicyclic monoterpene ketone, having antioxidant, anti-inflammatory and anti-apoptotic properties, was selected to investigate its efficiency in reversing CP-induced hepatotoxicity. We hypothesized that VRB having good antioxidant, anti-inflammatory and anti-apoptotic properties, might neutralize the CP-induced toxicity and offer liver protection.
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