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Pancreatic cancer continues to pose daily challenges to clinicians, radiologists, and researchers. These challenges are encountered at each stage of pancreatic cancer management, including early detection, definite characterization, accurate assessment of tumour burden, preoperative planning when surgical resection is possible, prediction of tumour aggressiveness, response to treatment, and detection of recurrence. CT imaging of the pancreas has made major advances in recent years through innovations in research and clinical practice. Technical advances in CT imaging, often in combination with imaging biomarkers, hold considerable promise in addressing such challenges. Ongoing research in dual-energy and spectral photon-counting computed tomography, new applications of artificial intelligence and image rendering have led to innovative implementations that allow now a more precise diagnosis of pancreatic cancer and other diseases affecting this organ. This article aims to explore the major research initiatives and technological advances that are shaping the landscape of CT imaging of the pancreas. By highlighting key contributions in diagnostic imaging, artificial intelligence, and image rendering, this article provides a comprehensive overview of how these innovations are enhancing diagnostic precision and improving outcome in patients with pancreatic diseases.
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http://dx.doi.org/10.1177/08465371251319965 | DOI Listing |
Cancer Res
September 2025
Massachusetts General Hospital, Charlestown, MA, United States.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, primarily due to late-stage diagnosis and limited treatment options. Zinc homeostasis is markedly dysregulated in PDAC, and this dysregulation can be probed by administering a secretagogue to stimulate zinc secretion (SSZS) in the exocrine pancreas and imaging with a zinc sensitive magnetic resonance imaging (MRI) probe. This study demonstrated the potential of SSZS MRI for sensitive detection, monitoring treatment response, and assessing recurrence after treatment withdrawal in PDAC.
View Article and Find Full Text PDFResearch (Wash D C)
September 2025
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
U-structure has become a foundational approach in medical image segmentation, consistently demonstrating strong performance across various segmentation tasks. Most current models are based on this framework, customizing encoder-decoder components to achieve higher accuracy across various segmentation challenges. However, this often comes at the cost of increased parameter counts, which inevitably limit their practicality in real-world applications.
View Article and Find Full Text PDFCell Mol Gastroenterol Hepatol
September 2025
West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
Background & Aims: Suppressing toxic Ca accumulation in pancreatic acinar cells (PACs) is the central therapeutic strategy of acute pancreatitis (AP). Store-operated Ca entry (SOCE) represents an important mechanism promoting Ca overload, which remains incompletely understood in AP. Transient receptor potential vanilloid 6 (TRPV6) is an ion channel highly selective to Ca, and its role in PACs or AP onset remains largely unknown.
View Article and Find Full Text PDFMed Phys
August 2025
QuantIF AIMS, University of Rouen, Rouen, France.
Background: Patient-specific dosimetry in radiopharmaceutical therapy (RPT) offers a promising approach to optimize the balance between treatment efficacy and toxicity. The introduction of 360° CZT gamma cameras enables the development of personalized dosimetry studies using whole-body single photon emission computed tomography and computed tomography (SPECT/CT) data.
Purpose: This study proposes to validate the collapsed-cone superposition (CCS) approach against Monte Carlo (MC) simulations for whole-body dosimetry of [177Lu]Lu-PSMA-617 therapy in patients with metastatic castration resistant prostate cancer (mCRPC).
Zhejiang Da Xue Xue Bao Yi Xue Ban
September 2025
Hepato-Biliary-Pancreas Surgery Section, Ningbo Medical Center Lihuili Hospital, Ningbo 315000, Zhejiang Province, China.
The clinical data of 10 patients with pathologically confirmed primary hepatic neuroendocrine neoplasms from Ningbo medical institutions between 2012 and 2024 were retrospectively analyzed. The cohort included 8 males and 2 females, with a median age of 63 years. None presented with carcinoid syndrome.
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