Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To investigate the effectiveness of formula nutrition supplementation (mainly containing glucosamine sulphate, chondroitin sulphate and rhizoma drynariae) plus supervised exercise versus exercise alone for the treatment of knee osteoarthritis (OA).
Methods: This was a double-blinded, single-centre, randomised, placebo-controlled trial. The study recruited 65 participants (40-75 years) with knee OA. Participants were randomly allocated to nutrition supplementation plus exercise (N + E) group or placebo plus exercise (P + E) group. The intervention lasted for 6 months. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Secondary outcomes included physical function and performance scores, lower extremity strength and serum biomarkers.
Results: Among the 65 randomised patients, 56 (86%) completed the trial. At 3 months, more participants in the N + E group than in the P + E group achieved minimum clinically important difference (MCID) in WOMAC total score (19/30 [63.3%] vs 8/26 [30.8%]; P < .01). At 6 months, more participants in the N + E group than in the P + E group achieved MCID in WOMAC stiffness score (19/30 [63.3%] vs 10/26 [38.5%]; P < .05). Meanwhile, at 6 months the decreased percentages of WOMAC stiffness score in the N + E group was greater than in the P + E group (P < .05). The flexor peak torque at 120°/s and 180°/s in the N + E group were significantly higher than those in the P + E group at 3 months (P < .05). Moreover, compared with baseline, improvements in the WOMAC overall and pain score, visual analogue scale pain and 30-second chair stand test were observed in both groups at 6 months. However, these indicators in the N + E group were improved as early as 3 months (P < .05).
Conclusions: The improvement effects of nutrition supplementation plus exercise were superior to those of exercise alone, and the improvement occurred earlier. Nutrition supplementation plus exercise would be a more efficient strategy for knee OA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ageing/afaf010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Daily Use of a Broad-Spectrum Cannabidiol Supplement Produces Detectable Concentrations of Cannabinoids in Urine Prohibited by the World Anti-Doping Agency: An Effect Amplified by Exercise.
Med Sci Sports Exerc
September 2025
Research Institute of Sport and Exercise Sciences (RISES), Liverpool John Moores University, Byrom Street, Liverpool, UNITED KINGDOM.
Background: Cannabidiol (CBD), a non-intoxicating phytocannabinoid, is used by athletes to enhance recovery and manage other conditions (e.g., poor sleep, anxiety).
View Article and Find Full Text PDFCost-effectiveness of oil and milk fortification by scale for reducing Vitamin A and Vitamin D deficiency in India.
PLoS One
September 2025
Institute of Economic Growth, Delhi University Enclave (North Campus), Delhi, India.
Background: Although broad-scale data might suggest low prevalence, millions of children in India still suffer from Vitamin A and Vitamin D deficiencies despite India's existing guidelines for Vitamin A deficiency. To address the issue, the Government of India has recommended fortification of oil and milk to improve Vitamin A and Vitamin D consumption. However, there is limited information on the health benefits and cost-effectiveness of fortifying oil and milk at scale.
View Article and Find Full Text PDFPluralistic ignorance of stigma impedes take-up of welfare benefits.
J Pers Soc Psychol
September 2025
Anderson School of Management, University of California, Los Angeles.
For the past decade, the United States spent hundreds of billions of dollars annually on public welfare programs, yet over 30% of eligible individuals do not access benefits distributed through these programs. We propose that a key barrier to program participation is miscalibrated perception of public stigma-individuals' pessimistic impressions of the stigma with which the general public regards welfare-eligible people. First, we examine how people's own attitudes toward a welfare-eligible individual compare to their estimates of parallel attitudes among their peers and among the general public.
View Article and Find Full Text PDFFermented Food Consumption Across European Regions: Protocol for the Development and Validation of the Web-Based Fermented Foods Frequency Questionnaire (3FQ).
JMIR Res Protoc
September 2025
Department of Food Science and Technology, Kaunas University of Technology, Kaunas, Lithuania.
Background: Fermented foods vary significantly by food substrate and regional consumption patterns. Although they are consumed worldwide, their intake and potential health benefits remain understudied. Europe, in particular, lacks specific consumption recommendations for most fermented foods.
View Article and Find Full Text PDFEffectiveness of Medical Nutrition Therapy in the Management of Patients with Obesity and Endometriosis: from the Mediterranean Diet To the Ketogenic Diet, Through Supplementation. The Role of the Nutritionist in Clinical Management.
Curr Obes Rep
September 2025
Department of Medicine, Division of Endocrinology, University of Arizona, Tucson, AZ, USA.
Purpose Of The Review: This review aimed to summarize current evidence on the effectiveness of medical nutrition therapy (MNT) in the management of obesity and endometriosis, with a focus on dietary patterns such as the Mediterranean and Ketogenic diets, as well as nutritional supplementation. Additionally, it highlights the central role of the clinical nutritionist in implementing individualized, evidence-based interventions within multidisciplinary care.
Recent Findings: Although the literature reports the existence of an inverse relationship between risk of endometriosis and body mass index, clinical evidence jointly reports that a condition of obesity is associated with greater disease severity.