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http://dx.doi.org/10.1016/j.ajog.2025.02.026 | DOI Listing |
J Affect Disord
September 2025
Department of Sociology, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Despite growing recognition of health as a multidimensional construct, few studies have examined how physical, psychological, and behavioral health dimensions coalesce and evolve across the transition from young to middle adulthood, especially within the context of life-course adversities. Existing research often focuses on isolated health indicators or overlooks the dynamic, fluid nature of health over time. Additionally, the combined effects of childhood and adulthood adversities on health transitions remain underexplored.
View Article and Find Full Text PDFHeart Rhythm
September 2025
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:
Background: The learning curve for pulmonary vein isolation (PVI) using "single-shot" pulsed-field ablation (PFA) is thought to be short. 3D electro-anatomical mapping (3D-EAM) might provide adjunctive information to shorten the learning curve and improve lesion durability.
Objective: To analyze procedural performance markers over time for PVI using PFA and 3D-EAM.
J ISAKOS
September 2025
OrthoIndy, Indianapolis, IN USA.
Introduction: The extent of change in Patient Reported Outcome Measures (PROs) required to meet surgeon-defined satisfactory outcomes after isolated Medial Patellofemoral Ligament Reconstruction (MPFL-R) has not been reported. The primary aim of the study was to define the threshold value of maximal outcome improvement (MOI) in PROs associated with surgeon-defined satisfactory postoperative outcomes. The secondary aim was to identify the most effective PRO in predicting these outcomes and to evaluate the factors associated with it.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Institute of Orthopedics and Traumatology, Military Hospital 175, Ho Chi Minh City, 70000, Viet Nam. Electronic address:
Introduction: Proximal humeral fracture-dislocations (PHF-D) are complex injuries, often requiring urgent intervention. However, management protocols remain unclear when anatomical reduction of the glenohumeral joint is achieved, but significant displacement of the greater tuberosity persists. The lack of consensus on whether to reclassify such injuries after reduction creates uncertainty in rehabilitation strategies.
View Article and Find Full Text PDFPhytomedicine
August 2025
Department of Parasitology and Tropical Medicine, and Institute of Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea. Electronic address:
Background: Primary amoebic meningoencephalitis (PAM), caused by Naegleria fowleri, poses a significant challenge in humans owing to its high mortality rate, exceeding 97 %. Current therapeutics have been unable to deliver satisfactory treatment outcomes, due to suboptimal efficacy and toxicity, highlighting the critical need for efficacious drug development. In this study, we identified a natural compound, 3,5-Dihydroxy-8‑methoxy-1-O-β-d-glucopyranosyl xanthone (DX), which exhibited promising anti-N.
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