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Introduction: Neurodevelopmental disorders (NDDs) have high comorbidity rates and shared etiology. Nevertheless, NDD assessment is diagnosis-driven and focuses on symptom profiles of individual disorders, which hinders diagnosis and treatment. There is also no evidence-based, standardized transdiagnostic approach currently available to provide a full clinical picture of individuals with NDDs. The pressing need for transdiagnostic assessment led to the development of the Neurodevelopment Assessment Scale (NAS).
Methods: This paper describes the co-design process used in the development of NAS prototype with stakeholders including individuals with NDDs, parents of children with NDDs, and health professionals.
Results And Discussion: Results indicated stakeholder consensus that NAS would be useful for NDD assessment, and included recommendations for fine-tuning the way some questions were asked (e.g., child's diagnoses), question flow (e.g., branching logic), and the language and presentation of the prototype (e.g., readability). Stakeholders also suggested the administration protocol should be flexible using electronic, face-to-face, online formats etc.
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http://dx.doi.org/10.3389/frcha.2025.1497632 | DOI Listing |
Environ Int
August 2025
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC, USA; Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC, USA. Electr
Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely impact child neurodevelopment; however, epidemiologic findings remain inconclusive because of small sample sizes, limited exposure variability, and differing neurodevelopmental measures. We aimed to investigate the relationship between prenatal PFAS exposure and child behavior.
Methods: We pooled data from nine study sites in the nationwide Environmental influences on Child Health Outcomes (ECHO) Cohort.
J Osteopath Med
September 2025
Rowan Integrated Special Needs Center (an affiliate of Virtua Medical Group), Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA.
Context: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by challenges in social communication and repetitive behaviors. Its etiology is influenced by a combination of genetic and environmental factors. Variations in the methylenetetrahydrofolate reductase (MTHFR) gene, which is implicated in folate metabolism and neurodevelopment, are widespread in the autism population.
View Article and Find Full Text PDFBiol Psychiatry Cogn Neurosci Neuroimaging
September 2025
Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center. Electronic address:
Background: The interthalamic adhesion (IA) is a midline structure connecting the left and right thalamus that typically develops during the 2 trimester of pregnancy. Missing and smaller IA has been linked to neurodevelopmental disorders, including schizophrenia, and subtle deficits in cognition. However, findings are inconsistent and the association between IA and other anatomical variants linked to atypical brain development in schizophrenia, including incomplete hippocampal inversion (IHI), is unclear.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China. Electronic address:
Synaptic plasticity is fundamental for cognitive development and brain function. Aluminium nanoparticles (AlNPs), widely used in industrial and consumer products, pose potential neurotoxic risks, particularly during early neurodevelopment. However, their effects on synaptic plasticity and cognitive outcomes remain poorly understood.
View Article and Find Full Text PDFFront Pediatr
August 2025
Division of Newborn Medicine, Tufts Medical Center, Boston, MA, United States.
Background: Medical imaging is essential in neonatal intensive care units (NICUs), particularly for the management of preterm infants. However, concerns persist regarding the neurodevelopmental impact of repeated low-dose radiation exposure. This study aimed to investigate whether cumulative x-ray exposure in the first month of life is associated with neurodevelopmental outcomes in preterm infants.
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