Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815939PMC
http://dx.doi.org/10.1016/j.gendis.2025.101533DOI Listing

Publication Analysis

Top Keywords

consequences varying
4
varying degrees
4
degrees alteration
4
alteration elucidated
4
elucidated knock-in
4
knock-in mouse
4
mouse models
4
models pseudogene
4
pseudogene contamination-free
4
contamination-free long-read
4

Similar Publications

Age-related changes in cardiolipin profile and functional consequences of altered fatty acid supply.

Biochim Biophys Acta Mol Cell Biol Lipids

September 2025

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany; Center for Molecular Biomedicine, Jena University Hospital, Hans-Knöll-Str. 2, 07745, Jena, Germany; Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum 1,

Cardiolipins (CLs) are primarily expressed in the inner mitochondrial membrane where they play essential roles in membrane architecture and mitochondrial functions. CLs have a unique structure characterized by four acyl chains with different stoichiometries such as chain length and degree of saturation. CL composition changes with disease and age, but it is largely unknown how dynamic changes affect mitochondrial function.

View Article and Find Full Text PDF

In vivo fusarium virulence and efficacy of voriconazole in a galleria mellonella model of invasive fusariosis.

J Microbiol Methods

September 2025

Université de Lorraine, SIMPA, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Laboratoire de Microbiologie, F-54000 Nancy, France. Electronic address:

Fusarium species are transkingdom pathogens involved in invasive fungal infections in immunocompromised patients. Despite high minimum inhibitory concentrations (MICs), voriconazole (VRZ) is the antifungal recommended as a first-line treatment for this infection. The objective of this study was to use larvae of the invertebrate Galleria mellonella to describe invasive Fusarium infection, evaluate the virulence profiles of a set of strains and determine the response of Fusarium to antifungal treatment.

View Article and Find Full Text PDF

SUMO-modified Tripartite Motif Protein 28 (TRIM28; KAP1) plays a crucial role in repressing endogenous retroelement (ERE) transcription. We previously provided evidence that loss of SUMO-modified TRIM28 triggered by influenza A virus (IAV) infection promotes activation of host antiviral immunity via a mechanism involving derepression of EREs and production of immunostimulatory RNAs. While the IAV NS1 protein might limit consequences of such activation via its dsRNA-binding activity, we hypothesized that other human pathogenic viruses could have evolved more direct strategies to counteract this potential ERE-based defense system.

View Article and Find Full Text PDF

Purpose Of Review: Diagnostic stewardship (DS) aims to optimise the use of laboratory testing to improve patient care while reducing unnecessary tests. This review examines recent evidence on DS interventions to optimise the use of resources, focusing on three key areas: reducing unnecessary testing, maximising the impact of existing tests, and avoiding the overdiagnosis of hospital-acquired infections.

Recent Findings: Multiple interventions have demonstrated effectiveness in reducing unnecessary blood and urine culture testing, including clinical decision support tools, education programs, and multidisciplinary approaches.

View Article and Find Full Text PDF

The environmental impact of Tire and Road Wear Particles (TRWP), arising from tire-road friction, has raised significant concerns. Like microplastics, TRWP contaminate air, water, and soil, with considerable annual emissions and runoff into freshwater ecosystems. Among TRWP compounds, 6PPD-Q, leached from tire particles, shows varying toxicity across species, notably affecting fish and invertebrates.

View Article and Find Full Text PDF