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Background: Patients undergoing laparoscopic radical nephrectomy (LRN) for renal cancer face multifaceted challenges that can affect their physical, psychological, and emotional well-being. This study aimed to evaluate the impact of nursing based on Peplau's theory on the recovery outcomes of patients treated with LRN for renal cancer, focusing on their nutritional status, spiritual well-being, and quality of life (QOL) after the surgical procedure.
Methods: A total of 148 patients with renal cancer who underwent LRN at our hospital between January 2023 and January 2024 were initially selected and grouped according to the type of postoperative nursing approach. Among the 75 patients receiving routine nursing, three with thrombosis of the renal vein or inferior vena cava and two with multiple renal tumours were excluded. Ultimately, 70 patients were included in the control group. Along with the routine nursing interventions, 73 patients received nursing care based on Peplau's interpersonal relationship theory. A total of 70 patients were categorised in the Peplau nursing group after excluding two with multiple renal tumours and one with a history of laparoscopic partial nephrectomy (LPN). Data on demographic characteristics, disease features, nutritional indices, Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp) scores, and QOL scores were collected and analysed using statistical tests.
Results: The haemoglobin ( < 0.001), albumin ( = 0.002), prealbumin ( = 0.013), and transferrin levels ( < 0.001) after nursing in the Peplau nursing group showed a significant increase compared to those in the control group. Moreover, the Peplau nursing group demonstrated significantly higher FACIT-Sp ( < 0.001) and QOL scores ( < 0.001) after nursing than the control group.
Conclusions: Nursing grounded in Peplau's interpersonal relationship theory may have a beneficial effect on the nutritional status, spiritual well-being, and QOL of patients undergoing LRN for renal cancer.
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http://dx.doi.org/10.56434/j.arch.esp.urol.20257801.10 | DOI Listing |
J Immunother Cancer
September 2025
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China
Neoadjuvant immunochemotherapy (nICT) has demonstrated significant potential in improving pathological response rates and survival outcomes for patients with locally advanced esophageal squamous cell carcinoma (ESCC). However, substantial interindividual variability in therapeutic outcomes highlights the urgent need for more precise predictive tools to guide clinical decision-making. Traditional biomarkers remain limited in both predictive performance and clinical feasibility.
View Article and Find Full Text PDFTransl Oncol
September 2025
Pharmacy of Jiangxi cancer hospital&institute, Nanchang, Jiangxi, China. Electronic address:
Background: Renal cell carcinoma (RCC) is a common malignant tumor with metabolic reprogramming and immune evasion features. δ-Aminolevulinic acid dehydratase (ALAD), a key enzyme in heme biosynthesis, has been implicated in cancer progression and treatment outcomes, but its role in RCC remains unclear.
Methods: This study integrated multi-omics datasets from TCGA, CPTAC, and GEO to analyze ALAD's expression, prognostic value, and functional implications in RCC.
Tissue Cell
September 2025
Department of Pathology, College of Medicine, King Khalid University, P.O. 641, Abha 61421, Saudi Arabia.
Cardiotoxicity remains a major clinical challenge associated with various environmental and chemotherapeutic toxicants. Sunitinib (SNB) is a potent targeted cancer drug that is reported to induce severe organ damage including renal failure. Cirsiliol (CSL) is a natural flavone that exhibits marvelous pharmacological properties.
View Article and Find Full Text PDFJCO Clin Cancer Inform
September 2025
USC Institute of Urology and Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Purpose: To evaluate a generative artificial intelligence (GAI) framework for creating readable lay abstracts and summaries (LASs) of urologic oncology research, while maintaining accuracy, completeness, and clarity, for the purpose of assessing their comprehension and perception among patients and caregivers.
Methods: Forty original abstracts (OAs) on prostate, bladder, kidney, and testis cancers from leading journals were selected. LASs were generated using a free GAI tool, with three versions per abstract for consistency.
Clin Nucl Med
September 2025
Department of Radiology and Nuclear Medicine, Comprehensive Cancer Care and Research Center (SQCCCRC), University Medical City, Muscat, Oman.
PSMA-targeted radioligand therapies with 177Lu-PSMA-617 have shown promising response rates with favorable toxicity in patients with metastasized castration-resistant prostate cancer. We report a case of a 72-year-old man with metastatic castration-resistant prostate cancer having comorbidities of DM, HTN, and end-stage renal disease (ESRD) on regular hemodialysis. The patient received 2 doses of 7.
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