Chromatographic and Spectroscopic Analyses of Cannabinoids: A Narrative Review Focused on Cannabis Herbs and Oily Products.

Molecules

Sciensano, Scientific Direction Physical and Chemical Health Risks, Medicines and Health Products Rue Juliette Wytsmanstraat, 14, 1050 Brussels, Belgium.

Published: January 2025


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Article Abstract

L. is cultivated nowadays for agricultural, industrial, and medicinal applications and also for recreational use. The latter is due to the presence of delta-9-tetrahydrocannabinol, a psychoactive substance. Recreational cannabis policies vary between different countries, which has led to the lack of a clearly defined legal context for cannabis and also a diversity of products derived from or containing cannabis on the (il)legal market. These cannabis-derived products have regained attention, notably because of their cannabinoid content. This review aims to assess and present analytical methods developed to analyze phytocannabinoids with spectroscopic and chromatographic techniques in specific cannabis matrices: herbs and oily products. Published papers from 2018-November 2024 were searched for with precise criteria, analyzed, and summarized. In the studies, liquid and gas chromatographic techniques (>70% reviewed papers) were the most used and have been widely applied using similar methods, and most papers were focused on cannabis herbs (>75%). Techniques were also compared and future challenges were identified. A comparison of different specificities of chromatographic and spectroscopic techniques discussed in this current review has also been established and summarized.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821174PMC
http://dx.doi.org/10.3390/molecules30030490DOI Listing

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