98%
921
2 minutes
20
Remimazolam, a novel short-acting benzodiazepine, has garnered interest in the realm of procedural sedation. Targeting a desired level of sedation requires a medication with both anesthetic and analgesic properties, particularly in non-operating room anesthetizing locations. Via gammaaminobutyric acid type A receptor agonism, Remimazolam has demonstrated organ-independent metabolism and rapid time to both onset and recovery and has efficacy for procedural sedation in clinical trials. This article provides a review of the current literature on the utility of remimazolam for procedural sedation.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272093 | PMC |
http://dx.doi.org/10.2174/011570159X367968250117034551 | DOI Listing |
J Clin Monit Comput
September 2025
Pediatric Intensive Care Unit, CHU Lille, 59000, Lille, France.
The Analgesia Nociception Index (ANI) has been used to assess discomfort in anesthetized adults. The COMFORT Behavior Scale (CBS) is recommended for assessing discomfort in intubated and sedated children. The primary objective of the present study was to assess the validity and performance of the ANI as an indicator of discomfort in intubated, ventilated children in a pediatric intensive care unit (PICU).
View Article and Find Full Text PDFAnn Afr Med
September 2025
Department of Anaesthesiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Introduction: Delirium, a common acute brain dysfunction in older adults, features rapid changes in attention, awareness, and thinking that fluctuate. It presents diversely with altered activity levels and sleep. Postoperative delirium (POD), often seen in the postanesthesia care unit, is a temporary mental status change, with hypoactivity being common.
View Article and Find Full Text PDFJ Cataract Refract Surg
September 2025
Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Purpose: To compare patient's reported pain perception between immediate sequential versus delayed sequential bilateral cataract surgery (ISBCS vs. DSBCS).
Setting: King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
BMJ Paediatr Open
September 2025
Division of Medical Critical Care, Boston Children's Hospital, Boston, Massachusetts, USA.
Background: Limited evidence exists on the additive risk of bradycardia in children with respiratory syncytial virus (RSV) bronchiolitis receiving dexmedetomidine (DMED). We aim to study the association between RSV bronchiolitis and bradycardia during DMED administration.
Methods: This retrospective cohort study included 273 children under 2 years old admitted to the intensive care units at Boston Children's Hospital with severe bronchiolitis and sedated with DMED from 2009 to 2022.
JMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.