Cyclase-associated protein: an actin regulator with multiple neuronal functions.

Trends Cell Biol

Molecular Neurobiology Group, Institute of Physiological Chemistry, Philipps University of Marburg, 35032 Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus-Liebig-University Giessen, Hans-Meerwein-Strasse 6, 35032 Marburg, Germany.

Published: April 2025


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Article Abstract

Studies of the past decade established cyclase-associated protein (CAP) as a key regulator of actin dynamics and associated its dysregulation with human brain disorders. However, its neuronal functions remained unknown until recent studies deciphered CAP-dependent mechanisms relevant for neuron differentiation or synapse morphogenesis, which are summarized and discussed in this forum article.

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http://dx.doi.org/10.1016/j.tcb.2025.01.007DOI Listing

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