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Studies of the past decade established cyclase-associated protein (CAP) as a key regulator of actin dynamics and associated its dysregulation with human brain disorders. However, its neuronal functions remained unknown until recent studies deciphered CAP-dependent mechanisms relevant for neuron differentiation or synapse morphogenesis, which are summarized and discussed in this forum article.
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http://dx.doi.org/10.1016/j.tcb.2025.01.007 | DOI Listing |
Front Pharmacol
August 2025
Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, Brazil.
6-Nitrodopamine (6-ND) has potent positive chronotropic and inotropic effects. At a very low dose, i.e.
View Article and Find Full Text PDFbioRxiv
August 2025
Division of Nano Life Science, Graduate School of Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.
Cyclase-associated protein (CAP) binds to both actin monomers and filaments and regulates multiple aspects of the actin dynamics including polymerization and depolymerization. CAP has been isolated from multiple species as a stable equimolar complex with actin monomer. However, functional significance of the CAP-actin complex is unknown.
View Article and Find Full Text PDFBMC Cardiovasc Disord
July 2025
Clinical School of Thoracic, Tianjin Medical University, Tianjin, China.
Background: Cardiovascular diseases, particularly atherosclerosis, remain a leading cause of global mortality, presenting significant challenges with non-ST-segment elevation myocardial infarction (NSTEMI). Novel biomarkers such as cluster of differentiation 47 (CD47) and adenylate cyclase-associated protein 1(CAP1) have emerged as potential candidates for improving early diagnosis and risk stratification in NSTEMI patients.
Methods: This prospective cohort study was conducted at Tianjin Chest Hospital from November 2023 to June 2024, involving a total of 270 patients categorized into NSTEMI and unstable angina (UA) groups.
Emerg Microbes Infect
December 2025
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People's Republic of China.
is the most prevalent pathogenic mould that contributes to high morbidity and mortality in immunocompromised patients. Here, we characterized the functions of the cyclase-associated protein (CAP) in . To study the role of CAP in virulence and antifungal susceptibility of , gene knockout strain () and complemented strain (R-) were constructed.
View Article and Find Full Text PDFActa Pharm Sin B
March 2025
State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China.
[This corrects the article DOI: 10.1016/j.apsb.
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