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Article Abstract
Integrating fluorine into heterocyclic structures cyclization reactions under metal-free conditions is attractive for organic synthesis. Herein, we describe solvent dependent fluorinative cyclizations of -hydroxyarylenaminones, which were promoted by HO and NFSI under metal-free conditions, to furnish 2,3-substituted chromanones. Di- and monofluorinated 2-hydroxyl chromanones could be achieved selectively in a THF-HO or EtOH-HO system at ambient temperature under an air atmosphere.
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