Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00401-025-02851-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300.
Elife
May 2025
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, United States.
Studies on Hippo pathway regulation of tumorigenesis largely center on YAP and TAZ, the transcriptional co-regulators of TEADs. Here, we present an oncogenic mechanism involving VGLL and TEAD fusions that is Hippo pathway-related but YAP/TAZ-independent. We characterize two recurrent fusions, and , recently identified in human spindle cell rhabdomyosarcoma.
View Article and Find Full Text PDFVGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300.
bioRxiv
February 2025
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.
Studies on Hippo pathway regulation of tumorigenesis largely center on YAP and TAZ, the transcriptional co-regulators of TEAD. Here, we present an oncogenic mechanism involving VGLL and TEAD fusions that is Hippo pathway-related but YAP/TAZ-independent. We characterize two recurrent fusions, VGLL2-NCOA2 and TEAD1-NCOA2, recently identified in spindle cell rhabdomyosarcoma.
View Article and Find Full Text PDFA rare case of congenital spindle cell rhabdomyosarcoma with TEAD1-NCOA2 fusion: A subset of spindle cell rhabdomyosarcoma with indolent behavior.
Pathol Int
April 2020
Department of Pathology, National University of Singapore, Singapore, Singapore.
A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases.
Am J Surg Pathol
February 2016
Departments of *Pathology‡Pediatric Hematology-Oncology, University of Padova§Institute of Pediatric Research Città della Speranza, Padova, ItalyDepartments of †Pathology∥Surgery¶Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY.
Sclerosing rhabdomyosarcoma (ScRMS) and spindle cell rhabdomyosarcoma (SRMS) have been recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS. Genetically, a subset of the congenital cases display NCOA2 gene rearrangements, whereas tumors occurring in older children or adults harbor MYOD1 gene mutations with or without coexisting PIK3CA mutations. Despite these recent advances, a significant number of tumors lack known genetic alterations.
View Article and Find Full Text PDF