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http://dx.doi.org/10.1016/j.jcmg.2024.10.013 | DOI Listing |
Eur Heart J Cardiovasc Imaging
August 2025
Medizinische Klinik und Poliklinik I, LMU Klinikum, Munich, Germany.
Background: Management of transcatheter aortic valve replacement (TAVR) in aortic stenosis (AS) flow-groups-high-gradient (HG-AS), classical low-flow low-gradient (cLFLG-AS), and paradoxical low-flow low-gradient (pLFLG-AS)-is debated. Concomitant mitral regurgitation (MR) worsens outcomes, but the influence of MR etiology on AS subtypes is unclear.
Aims: To evaluate the impact of MR etiology and severity on outcomes across AS flow groups in TAVR patients.
Echocardiography
August 2025
Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
Purpose: Patients with aortic stenosis (AS) may have discordant severity grades between AS by aortic valve area (AS) and AS using hemodynamic-based guidelines (AS). Individuals with normal left ventricular function and normal-flow low-gradient (NF-LG) AS that is moderate or severe by AVA are downgraded in severity by current guidelines. We evaluated the prevalence and risk of NF-LG AS in patients with moderate or severe AS.
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March 2025
Department of Cardiology, Odense University Hospital, J.B. Winsløws Vej 4, Odense 5000, Denmark.
Aims: This study aims to describe the prevalence of discordant mild/moderate aortic stenosis (AS) in a population-based study and to identify the mechanisms that lead to reduced stroke volume (SV) and discordant moderate AS.
Methods And Results: Discordant high-gradient (HG)-mild AS, defined as AVA > 1.5 cm2 and mean pressure gradient (MG) of 20-40 mmHg, and discordant low-gradient (LG) moderate AS, defined as AVA 1.
JACC Cardiovasc Imaging
February 2025
Department of Cardiology, Houston Methodist Hospital and The DeBakey Heart and Vascular Center, Houston, Texas, USA. Electronic address:
Am J Cardiol
May 2025
Departments of Cardiovascular Medicine. Electronic address:
This study sought to explore the clinical factors associated with classical low-flow low-gradient (C-LFLG) and normal-flow low-gradient (NFLG) aortic stenosis (AS) compared with high-gradient (HG) AS. We also compared clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) across flow-gradient patterns. Patients with C-LFLG AS have a higher mortality rate after TAVR than those with HG AS.
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