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The usage of broad sets of training data is paramount to evolve adaptive agents. In this respect, competitive co-evolution is a widespread technique in which the coexistence of different learning agents fosters adaptation, which in turn makes agents experience continuously varying environmental conditions. However, a major pitfall is related to the emergence of endless limit cycles where agents discover, forget and rediscover similar strategies during evolution. In this work, we investigate the use of competitive co-evolution for synthesizing progressively better solutions. Specifically, we introduce a set of methods to measure historical and global progress. We discuss the factors that facilitate genuine progress. Finally, we compare the efficacy of four qualitatively different algorithms, including two newly introduced methods. The selected algorithms promote genuine progress by creating an archive of opponents used to evaluate evolving individuals, generating archives that include high-performing and well-differentiated opponents, identifying and discarding variations that lead to local progress only (i.e., progress against the opponents experienced and retrogressing against others). The results obtained in a predator-prey scenario, commonly used to study competitive evolution, demonstrate that all the considered methods lead to global progress in the long term. However, the rate of progress and the ratio of progress versus retrogressions vary significantly among algorithms. In particular, our outcomes indicate that the Generalist method introduced in this work outperforms the other three considered methods and represents the only algorithm capable of producing global progress during evolution.
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http://dx.doi.org/10.3389/frobt.2024.1470886 | DOI Listing |
One Health Outlook
September 2025
Department of Tropical Health, High Institute of Public Health, Alexandria University, 165 El Horreya Road, Alexandria, 21561, Egypt.
Background: Brucellosis remains a significant public health and economic challenge in Egypt despite long-standing control efforts. This paper outlines the national strategy for brucellosis control, detailing its legal framework, diagnostic protocols, surveillance mechanisms, vaccination programs, and biosecurity measures.
Main Body: Egypt employs a dual approach of test-and-slaughter and selective vaccination, supported by serological and pathological diagnostics.
Nat Aging
September 2025
Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA.
Clinical Alzheimer's disease is currently characterized by cerebral β-amyloidosis associated with cognitive impairment. However, most cases of Alzheimer's disease are associated with multiple neuropathologies at autopsy. The peripheral protein changes associated with these disease endophenotypes are poorly understood.
View Article and Find Full Text PDFNat Rev Urol
September 2025
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Low-grade non-muscle invasive bladder cancer is a specific category of bladder cancer with a favourable prognosis; however, its management presents several challenges. The risk of stage progression is very low, but approximately half of patients will experience recurrence within the first 5 years after diagnosis. This high propensity for recurrence, coupled with the threat of progression, mandates ongoing surveillance.
View Article and Find Full Text PDFJ Cataract Refract Surg
July 2025
Department of Ophthalmology, Santo António Local Health Unit, Porto, Portugal.
Purpose: To demonstrate the efficacy and safety of iris-claw phakic intraocular lens (pIOL) in the treatment of post keratoplasty astigmatism.
Setting: Cornea Unit, Ophthalmology Department - Unidade Local de Saúde de Santo António - Porto, Portugal.
Design: Retrospective longitudinal study.
Methods Cell Biol
September 2025
Histology and Cell Biology Department, School of Medicine, Complutense University of Madrid, Madrid, Spain. Electronic address:
Parkinson disease (PD) is the second most prevalent neurodegenerative disorder globally, trailing only Alzheimer´s disease. It currently affects nearly 3 % of individuals aged 65 and above. The disease is characterized by the progressive loss of dopaminergic neurons accompanied by a chronic neuroinflammatory process, which is responsible for both motor symptoms (tremor, rigidity, bradykinesia) and non-motor symptoms (depression, dysphagia, anxiety, constipation, and anosmia).
View Article and Find Full Text PDF