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Prcis: Data coming from this study suggest that selective laser trabeculoplasty could be a very important tool in the overall management of glaucoma patients at every stage, aiming to better control the visual field deterioration.
Purpose: To evaluate selective laser trabeculoplasty (SLT) effectiveness in lowering intraocular pressure (IOP) and in visual field defect progression in eyes affected by primary open angle glaucoma (POAG) at long-term follow-up.
Methods: A retrospective study was conducted with 67 eyes of 67 patients affected by POAG who underwent SLT between 2014 and 2021. Each patient was routinely observed in the Glaucoma Office of Università della Campania Luigi Vanvitelli and underwent a complete eye visit and visual field test with 30-2 SITA standard automated perimetry (SAP) every 6 months. When both eyes in the same patient were treated, only the eye with a lower mean deviation (MD) of SAP was included. Patients were observed at 6, 12, 18, 24, 30, 36, 42, 48, and 54 months.
Results: A mean significant ( P <0.01) lower IOP was detected at 6 months (12.92±2.7 mm Hg) and at 54 months (13.08±2.42 mm Hg) compared with baseline (17.91±4 mm Hg). Mean MD values showed significant ( P <0.01) reduction both at the 6-month follow-up (-0.07±0.21dB) and at the 54-month follow-up (-0.3±0.34dB), demonstrating satisfactory clinical deceleration of the progression of the disease.Mean IOP medical lowering therapy was 1.34±0.9 drugs, showing a significant ( P <0.01) decrease 6 months after SLT (0.87±0.85), that remained stable [ P = at 54 mo follow up (0.9±0.76)].
Conclusions: The results observed confirm not only the high level of effectiveness of SLT in lowering IOP and reducing the need for topical medications but also its role in decelerating visual field deterioration in eyes affected by POAG.
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http://dx.doi.org/10.1097/IJG.0000000000002547 | DOI Listing |
J Craniofac Surg
September 2025
Department of Breast Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shijingshan, Beijing, China.
Background: With the development of artificial intelligence, obtaining patient-centered medical information through large language models (LLMs) is crucial for patient education. However, existing digital resources in online health care have heterogeneous quality, and the reliability and readability of content generated by various AI models need to be evaluated to meet the needs of patients with different levels of cultural literacy.
Objective: This study aims to compare the accuracy and readability of different LLMs in providing medical information related to gynecomastia, and explore the most promising science education tools in practical clinical applications.
Photobiomodul Photomed Laser Surg
September 2025
Department of Oral and Maxillofacial Diagnostic Sciences, Dental College and Hospital, Taibah University, Medina, Saudi Arabia.
Photobiomodulation (PBM) therapy involves the use of low-dose, nonionizing light to reduce pain and inflammation, promote wound healing, and enhance tissue regeneration. PBM-based therapy of various dental conditions is associated with improved treatment outcomes. This study aims to critically review the literature to highlight the underlying molecular biological mechanisms and clinical applications of PBM in modern dental practice.
View Article and Find Full Text PDFBeilstein J Nanotechnol
September 2025
B. I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
In this study, silicon nanoparticles (NPs) were produced by pulsed laser ablation in a liquid, aiming to investigate the influence of a laser beam profile on the properties of the resultant NPs. Morphology, inner structure, and phase composition of the formed NPs were characterized by means of ultraviolet-visible spectroscopy, high-resolution transmission electron microscopy, and Raman and photoluminescence spectroscopies, and the correlation of the NP properties with the laser beam profile was studied. Three different beam profiles were selected, namely, a Bessel beam produced using an axicon, an annular profile formed using a combination of an axicon and a converging lens, and a Gaussian beam focused on the surface of a Si target using the same converging lens.
View Article and Find Full Text PDFBackground: Functional and structural studies of the brain highlight the importance of white matter alterations in schizophrenia. However, molecular studies of the alterations associated with the disease remain insufficient.
Aim: To study the lipidome and transcriptome composition of the corpus callosum in schizophrenia, including analyzing a larger number of biochemical lipid compounds and their spatial distribution in brain sections, and corpus callosum transcriptome data.
Clin Ophthalmol
September 2025
Helen Keller Eye Research Foundation, Birmingham, AL, USA.
Rhegmatogenous retinal detachment (retinal detachment, RD) is the most common cause of spontaneous vision loss in aging eyes that were seeing normally until the moment of its occurrence. Causative retinal breaks usually occur in the form of peripheral tears at the vitreous base, resulting from traction exerted by the aging vitreous as it detaches posteriorly. Peripheral encircling laser retinopexy increases retinal resistance to vitreous traction in high-risk eyes.
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