98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/jdv.20568 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202.
Retinal ganglion cells (RGCs) are highly compartmentalized neurons whose long axons serve as the sole connection between the eye and the brain. In both injury and disease, RGC degeneration occurs in a similarly compartmentalized manner, with distinct molecular and cellular responses in the axonal and somatodendritic regions. The goal of this study was to establish a microfluidic-based platform to investigate RGC compartmentalization in both health and disease states.
View Article and Find Full Text PDFJ Speech Lang Hear Res
September 2025
University of the Witwatersrand, Johannesburg, South Africa.
Background: The integration of digital health care technologies into speech-language pathology and audiology is rapidly transforming service delivery. In South Africa and other low- and middle-income countries (LMICs), digital tools offer significant opportunities to address access challenges and enhance patient outcomes. However, the adoption of these technologies requires careful consideration of contextual factors.
View Article and Find Full Text PDFJ Biopharm Stat
September 2025
Biostatistics and Research Decision Sciences, Merck & Co. Inc., North Wales, Pennsylvania, USA.
A randomized clinical trial with multiple experimental groups and one common control group is often used to speed up development to select the best experimental regimen or to increase the chance of success of clinical trials. Most of the time, multiple dose levels of an experimental drug or multiple combinations of one experimental drug with other drugs comprise multiple experimental groups. Because the experimental drug appears in multiple comparisons with a shared control group, multiple testing adjustments to control the family-wise type I error rate are needed.
View Article and Find Full Text PDFBrain Behav
September 2025
Faculty of Economics and Administrative Sciences, Kilis 7 Aralık University, Kilis, Turkey.
Purpose: Stakeholder pressure is widely recognized as a key driver of green innovation. However, existing research often overlooks how this relationship may differ across various industry settings and national contexts. Understanding these contextual differences is essential for businesses aiming to implement effective and responsive environmental strategies.
View Article and Find Full Text PDFAnn Gastroenterol Surg
September 2025
We reviewed the current status and perspectives on salvage esophagectomy for initially unresectable locally advanced esophageal squamous cell carcinoma (ESCC) in the era of minimally invasive surgery and immunotherapy. Although the standard treatment for these patients is definitive chemoradiotherapy (CRT), the complete response rate to CRT alone remains unsatisfactory. Salvage esophagectomy, which is defined as surgery for residual or recurrent lesions after definitive CRT, is considered a curative treatment in clinical practice.
View Article and Find Full Text PDF