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Chiroptical resonances with high quality factors (Q factors) have recently garnered extensive attention due to their broad applications in lasing and optical sensing. However, the independent manipulation of the Q factor and circular dichroism (CD) of chiroptical resonances has rarely been proposed. Here, we demonstrate that the Q factor and CD of guided mode resonance (GMR) can be independently manipulated by simply varying two structural parameters in a diatomic dielectric metasurface grating, offering a new paradigm for chiroptical resonance manipulation. We reveal that the independent manipulation of the Q factor and CD of the GMR is attributed to the modulation of the collective interference of guided mode fields excited by the two orthogonal linearly polarized normal incidence. GMRs with a Q factor of 183 and CD of ±0.62 have been experimentally validated, which is comparable to state-of-the-art chiral quasi-BICs. These findings provide a powerful platform for the realization of high-Q chiroptical resonances.
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http://dx.doi.org/10.1021/acs.nanolett.4c06157 | DOI Listing |
Acc Chem Res
September 2025
Department of Chemistry, FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street W, Montréal, Québec H3A 0B8, Canada.
ConspectusMolecular photochemistry, by harnessing the excited states of organic molecules, provides a platform fundamentally distinct from thermochemistry for generating reactive open-shell or spin-active species under mild conditions. Among its diverse applications, the resurgence of the Minisci-type reaction, a transformation historically reliant on thermally initiated radical conditions, has been fueled by modern photochemical strategies with improved efficiency and selectivity. Consequently, the photochemical Minisci-type reaction ranks among the most enabling methods for C()-H functionalizations of heteroarenes, which are of particular significance in medicinal chemistry for the rapid diversification of bioactive scaffolds.
View Article and Find Full Text PDFNat Prod Rep
September 2025
Centre for Superbug Solutions, Australia.
Covering: January 2014-June 2025. Previous review: , 2014, , 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery of transformative drugs like morphine and quinine. The mid-20th century marked a 'golden age' for antibiotic discovery from natural sources, which then expanded into other therapeutic areas.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, 1 M. Kogalniceanu Street, 400084, Cluj-Napoca, Romania.
Magnetic nanoparticles are widely explored in biomedical applications, particularly as MRI contrast agents and for magnetic hyperthermia. However, their photothermal capabilities under near-infrared (NIR) irradiation remain underexplored in realistic, tissue-like environments. This study provides a comprehensive assessment of ultrasmall FeO nanoparticles (9.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Anorectal, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Previous studies have suggested a potential preventive effect of aspirin on colorectal cancer (CRC), but the causal relationship remains unclear. Based on the summary statistics of genome-wide association studies, Mendelian randomization (MR) method was used to assess the genetically predicted effect of aspirin use on CRC risk. Inverse variance weighted (IVW) was used as the main analysis method.
View Article and Find Full Text PDFDiscov Ment Health
September 2025
School of Health and Welfare, Dalarna University, Falun, Sweden.
Objective: To provide an overview of mental health problems throughout the postpartum period and to describe the screening instruments as well as associated factors related to the relevant population.
Methods: The scoping study was guided by the framework outlined by Arksey and O'Malley and Levac et al. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guideline was used to report the findings including citation backtracking.