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http://dx.doi.org/10.1177/01455613251316149 | DOI Listing |
J Integr Neurosci
August 2025
Department of Neurology, Peking University First Hospital Taiyuan Hospital, 030000 Taiyuan, Shanxi, China.
Background: Remote ischemic conditioning (RIC), a novel neuroprotective therapy, has broad potential for reducing the occurrence and recurrence of cerebrovascular events, yet its mechanisms are not incompletely understood. The aim of this study is to investigate whether RIC alleviates apoptosis, inflammation, and reperfusion injury in rat models of ischemic stroke by regulating the Elabela (ELA)-apelin-Apelin receptor (APJ) system.
Methods: We established a rat model of middle cerebral artery occlusion (MCAO) with ischemia-reperfusion injury, and RIC was administered twice daily for 3 days post-MCAO.
Cureus
August 2025
Psychiatry, Rashid Hospital, Dubai Health, Dubai, ARE.
Moyamoya disease (MMD) is a rare and progressive cerebrovascular disorder characterized by stenosis of the internal carotid arteries and their major branches, leading to the development of abnormal collateral vessels. While MMD is traditionally associated with ischemic and hemorrhagic strokes, there is increasing recognition of the psychiatric symptoms that can accompany the disease, which significantly impact patient outcomes and complicate management. This case report presents a 30-year-old female with a history of recurrent ischemic strokes, hypertension, diabetes, and dyslipidemia, who initially presented with neurological symptoms including headache, left-sided weakness, and facial deviation.
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Introduction: Ischemic stroke is a leading cause of mortality and disability worldwide, with limited therapeutic options and high rates of recurrence. Mitochondrial dysfunction plays a critical role in neuronal injury during ischemia-reperfusion, making mitochondrial autophagy a potential therapeutic target. Gypenoside XLIX, a major active metabolite of Gynostemma pentaphyllum, exhibits antioxidant and organ-protective properties, but its effects on neuronal mitochondrial damage in stroke remain unclear.
View Article and Find Full Text PDFEur Heart J Case Rep
September 2025
GNH Klinikum Kassel, Center for Cardiac Care, Mönchebergstraße 41-45, Kassel 34125, Germany.
Background: Pacemaker implantation has become a routine procedure in contemporary cardiology. Several possible complications during and after the procedure have been described, with this article focusing on the rare complication and the prevention of left-sided lead placement after arterial puncture.
Case Summary: A 90-year-old female patient was admitted to our hospital due to recurrent transient ischaemic attacks following a dual-chamber pacemaker implantation six weeks earlier.
Front Med (Lausanne)
August 2025
Royal College of Surgeons in Ireland - Bahrain, Al-Muharraq, Bahrain.
Introduction: Ischemic heart disease (IHD) remains a major global health burden, highlighting the urgent need for early, non-invasive diagnostic biomarkers. MicroRNAs (miRNAs), small non-coding RNA molecules that regulate gene expression, have emerged as promising candidates due to their stability in circulation and involvement in cardiovascular processes. This systematic review aimed to evaluate the potential of specific miRNAs as early diagnostic biomarkers in IHD.
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