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Article Abstract
Background: Polymethyl methacrylate (PMMA) is ideal for denture bases but is prone to biofilm accumulation, leading to denture stomatitis (DS), often involving . Dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) are introduced into dental materials for their antimicrobial and protein-repellent properties. This study investigates the effects of incorporating dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) into heat-polymerized (HP) and 3D-printed (3DP) denture base resins on microbial adhesion and cytotoxicity.
Methods: HP and 3DP denture base specimens were prepared using varying concentrations of DMAHDM and MPC. Microbial adhesion was quantified using CFU counts of , and cytotoxicity was assessed via an MTT assay using fibroblast cells after 24 h, 3 days, and 7 days.
Results: Both DMAHDM and MPC significantly reduced the CFU counts in both HP and 3DP materials; the combination of 1.5% DMAHDM and 3% MPC exhibited the most substantial antimicrobial effects. Cytotoxicity results varied between materials and time points; however, all treated groups maintained cell viability above the 70% threshold, indicating no significant cytotoxic effects.
Conclusion: Incorporating DMAHDM and MPC into denture base resins can effectively reduce microbial adhesion while maintaining acceptable cytotoxicity levels.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11768527 | PMC |
| http://dx.doi.org/10.3390/polym17020228 | DOI Listing |
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