Grape Pomace: A Review of Its Bioactive Phenolic Compounds, Health Benefits, and Applications.

Molecules

Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, E.N. 10 ao km 139.7, 2695-066 Bobadela LRS, Portugal.

Published: January 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

The wine industry generates high amounts of waste, posing current environmental and economic sustainability challenges. Grape pomace, mainly composed of seeds, skins, and stalks, contains significant amounts of bioactive compounds and constitutes the main solid residue of this industry. Various strategies are being explored for its valorization, from a circular economy perspective. This review provides an updated overview of the composition of grape pomace from winemaking, highlighting sustainable methodologies for extracting phenolic compounds and their potential health benefits, including antioxidant, antimicrobial, antidiabetic, cardioprotective, antiproliferative, anti-aging, and gut health properties. Furthermore, this review explores the potential applications of this agro-industrial waste and its extractable compounds across the food, cosmetic, and pharmaceutical sectors.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767471PMC
http://dx.doi.org/10.3390/molecules30020362DOI Listing

Publication Analysis

Top Keywords

grape pomace
12
phenolic compounds
8
health benefits
8
pomace review
4
review bioactive
4
bioactive phenolic
4
compounds
4
compounds health
4
benefits applications
4
applications wine
4

Similar Publications

With the development of people's diets and working patterns, obesity is an increasingly serious health threat faced globally. Grape pomace is an important by-product generated during the wine production process which is rich in polyphenols. Polyphenols show promising potential in anti-inflammatory, antioxidant, and metabolic regulatory applications.

View Article and Find Full Text PDF

Valorization of Carménère Grape Pomace: Extraction, Microencapsulation, and Evaluation of the Bioactivity of Polyphenols in Caco-2 Cells.

Int J Mol Sci

August 2025

Centro de Excelencia en Nanotecnología Leitat Chile, Fundación Leitat Chile, Román Díaz 532, Providencia, Santiago 8380000, Chile.

Grape pomace is a major by-product of winemaking and a rich source of phenolic compounds with antioxidant potential. The Carménère variety, emblematic of Chilean viticulture, remains underutilized despite its high anthocyanin and flavanol content. This study aimed to develop a cost-effective method to recover and stabilize bioactive compounds from Carménère grape pomace.

View Article and Find Full Text PDF

Grape Pomace and Ferulic Acid Improve Antioxidant Enzyme Activity and Gut Histomorphometry in Heat-Stressed Finishing Pigs.

Animals (Basel)

August 2025

Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera Gustavo Enrique Astiazarán Rosas, No. 46, Col. La Victoria, Hermosillo 83304, Sonora, Mexico.

Given the restrictions on animal growth promoters, alternative plant-based additives-particularly those rich in phenolic compounds, such as agro-industrial by-products-have been explored. These additives help to mitigate heat stress, which negatively affects productivity by impacting intestinal health and antioxidant status. This study evaluated the effects of individual and combined supplementation of ferulic acid (FA) and grape pomace (GP) on antioxidant enzyme activity, as well as intestinal histomorphometry, in finishing pigs under heat stress.

View Article and Find Full Text PDF

In this study, a green hydrothermal synthesis method was employed to produce and /β-MnO nanostructures using EET-50, an organic extract obtained from a by-product of Carménère wine production. The biomolecules in EET-50 acted as reducing agents due to their electron-donating functional groups, enabling nanostructure formation without the need for additional chemical reductants. Morphological characterization by SEM revealed that a KMnO/EET-50 mass ratio of 3:1 led to the synthesis of nano-octahedra alongside rod-like structures, with shorter reaction times favoring the development of isolated nano-octahedra ranging from 100 nm to 170 nm.

View Article and Find Full Text PDF

Grape pomace, a by-product of winemaking, has emerged as a promising source of natural antimicrobial compounds for food applications. In response to increasing concerns regarding foodborne illnesses and consumer demand for clean-label products, its valorization represents a sustainable approach to enhance food safety and shelf life. This review combines a bibliometric analysis with a critical examination of the scientific literature.

View Article and Find Full Text PDF