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Article Synopsis
- LINE-1s are a significant group of retrotransposons that can replicate themselves autonomously and are especially active in early embryo development, despite potential risks to genetic integrity.
- The study highlights a specific type of LINE-1, called L1Md_Ts, which is influenced by the ELL3 protein and acts as an enhancer in mouse embryonic stem cells, facilitating gene expression.
- ELL3’s role includes repressing the L1Md_T enhancer in the Akt3 gene, crucial for cell signaling, which helps regulate early development processes and transitions in embryonic stem cell states.
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The super elongation complex (SEC) has been reported to play a key role in the proliferation and differentiation of mouse embryonic stem cells. However, the expression pattern and function of the SEC in the inner ear has not been investigated. Here, we studied the inner ear expression pattern of three key SEC components, AFF1, AFF4, and ELL3, and found that these three proteins are all expressed in both cochlear hair cells (HCs)and supporting cells (SCs).
View Article and Find Full Text PDFDisruption of CTCF Boundary at HOXA Locus Promote BET Inhibitors' Therapeutic Sensitivity in Acute Myeloid Leukemia.
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Both HOX gene expression and CTCF regulation have been well demonstrated to play a critical role in regulating maintenance of leukemic stem cells (LSCs) that are known to be resistant to BET inhibitor (BETi). To investigate the regulatory role of CTCF boundary in aberrant HOX gene expression and the therapeutic sensitivity of BETi in AML, we employed CRISPR-Cas9 genome editing technology to delete 47 base pairs of the CTCF binding motif which is located between HOXA7 and HOXA9 genes (CBS7/9) in different subtypes of AML with either MLL-rearrangement or NPM1 mutation. Our results revealed that HOXA9 is significantly downregulated in response to the CBS7/9 deletion.
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