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The concept of "irreversibility" and its counterpart "reversibility" have become prominent in environmental and ecological research on human-induced changes, thresholds, climate tipping points, ecosystem degradation, and losses in the cryosphere and biosphere. Through a systematic literature review, we show that in these research fields, these notions are not only descriptive terms, but can have different semantic functions and normative aspects. The results suggest that, in the context of environmental and ecological research the concepts of irreversibility and reversibility have taken on additional usages in comparison to their contexts in theoretical thermodynamics and mechanics. Irreversible as a classification of anthropogenic environmental change can be used categorically, in the sense of a finite end, or relatively, i.e. on time or spatial scales of interest. Surprisingly, most of the analyzed scientific articles that use the terminology of (ir)reversibility substantively do not provide an explicit conceptualization or definition (74.7%). The research on potential (ir)reversibility of environmental change may affect the social and political willingness to bear the costs of interventions to mitigate or prevent undesirable environmental change. In particular, classifying a change as reversible or irreversible and determining the timescale(s) and spatial scale(s) involved has implications for policy and ecosystem management decisions, as suggested by its use in several high-level scientific and policy reports on ecosystem and climate change. Therefore, it is important to explicitly present a clear definition of irreversibility or reversibility for the readers from other fields, even if it could be the case that within a specific community an implicit definition was considered to be sufficient. We propose further recommendations for inter- and transdisciplinary reflection and conceptual use in the context of environmental, ecological, and sustainability research.
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http://dx.doi.org/10.1093/pnasnexus/pgae577 | DOI Listing |
Neurochem Int
September 2025
Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China; Advanced Medical Technology Center, the First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China; Key La
General anesthetics are essential in pediatric medicine, yet concerns persist regarding their potential neurotoxic effects on the developing brain. Whether transient synaptic disruptions caused by anesthesia lead to long-term deficits or are mitigated by endogenous plasticity remains unresolved. Here, we use longitudinal in vivo two-photon imaging in awake mice to investigate the structural and functional consequences of a single, clinically relevant exposure to sevoflurane at postnatal day 20.
View Article and Find Full Text PDFFood Chem
September 2025
School of Food Science and Technology, State Key Laboratory of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China. Electronic address:
Plant-based fat replacers have attracted considerable interest owing to their contributions to environmental sustainability, animal welfare, and health benefits. Their textural properties and flavor release behavior during processing are key determinants of their quality. Herein, a dual-network gel was produced using gellan gum and curdlan, which are thermally reversible and irreversible gel samples, respectively.
View Article and Find Full Text PDFNucl Med Biol
September 2025
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA. Electronic address:
Background: Positron-emission tomography (PET) imaging of the complement system could advance understanding of the innate immune system in central nervous system (CNS) diseases and development of new drugs. The goal of this study was to develop a PET radiotracer targeting the C3a receptor (C3aR) of the complement system.
Methods: C3aR radiotracer [F]1 was synthesized in one step.
Small
September 2025
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Modifying cells to achieve desired functions has attracted extensive attention in bioengineering and bio-manufacturing. Approaches based on cell-surface engineering have the potential to endow cells with multiple functions and also create a protective shell around them. However, such shells are generally irreversible and lack functionality, leading to various drawbacks associated with irreversible dynamics.
View Article and Find Full Text PDFMed Int (Lond)
August 2025
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan 410060, P.R. China.
S-glutathionylation (SSG), a redox-sensitive post-translational modification mediated by glutathione, regulates protein structure and function through reversible disulfide bond formation at cysteine residues. Glutaredoxins (GRXs), pivotal antioxidant enzymes, catalyze SSG dynamics to maintain thiol homeostasis. Recent advances in redox proteomics have revealed that SSG dysregulation is intricately linked to neurodegenerative, cardiovascular, pulmonary and malignant diseases.
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