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Background: Black women living with HIV (WLHIV) often have suboptimal ART adherence due to a multitude of social and structural barriers, including HIV-related stigma. Trust in healthcare providers plays a significant role in adhering to ART and is likely lower among Black WLHIV compared to their White counterparts. This study examined the relationship between experienced stigma in healthcare settings and ART adherence and viral suppression through anticipated stigma in healthcare settings, internalized stigma, and medical mistrust.
Participants/procedures: Participants included Black WLHIV from the Women's Interagency HIV Study (WIHS). We conducted serial mediation analyses where experienced HIV stigma in healthcare settings is associated with higher anticipated or internalized HIV stigma, leading to higher mistrust in HIV care providers, and ultimately, to lower ART adherence and viral suppression, adjusting for demographic and clinical covariates.
Results: Of the 1,060 WLHIV, approximately 84% achieved optimal ART adherence, and 65% had an undetectable viral load. Serial mediation analyses suggested significant indirect associations between experienced stigma in healthcare settings and ART adherence or viral suppression. Specifically, experienced stigma was associated with higher anticipated or internalized stigma, which was associated with mistrust in HIV care providers, resulting in lower ART adherence and reduced likelihood of undetectable viral load.
Conclusions: Interventions could focus on training healthcare providers to address implicit biases and create supportive healthcare environments. Integrating mental health support to reduce internalized stigma and using community engagement and education to address anticipated stigma may further improve trust in providers, leading to better health behaviors and outcomes.
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http://dx.doi.org/10.1016/j.socscimed.2025.117699 | DOI Listing |
Front Immunol
September 2025
Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.
Mesenchymal stromal cells (MSCs) are non-hematopoietic progenitor cells that can be derived from a variety of sources including bone marrow and adipose tissues among others. MSCs are plastic adherent and easy to culture , making them attractive platforms for cell-based technologies. They have an impressive immunoplasticity and can express a suppressive or inflammatory phenotype depending on their stimuli.
View Article and Find Full Text PDFBr J Clin Pharmacol
September 2025
Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano IRCCS, Aviano, Italy.
Aims: Pharmacogenetic implementation requires awareness of the state-of-the-art practice of laboratories providing pharmacogenetic testing. This study investigated how pharmacogenetic guidelines and recommendations have been implemented over time by Italian laboratories participating in the external quality assessment (EQA) Pharmaco-scheme established since 2019 by the European Molecular genetics Quality Network (EMQN).
Methods: Anonymized clinical pharmacogenetic reports submitted by Italian laboratories participating in the EMQN Pharmaco-scheme between 2019 and 2023 were analysed.
PLoS Med
September 2025
Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri, United States of America.
Background: Timely response to treatment failure is critical for improved outcomes and viral re-suppression among people living with HIV, but care gaps along the treatment failure cascade can occur due to delays by both clients (e.g., retention and adherence) and health systems (e.
View Article and Find Full Text PDFMatern Health Neonatol Perinatol
September 2025
Department of Obstetrics and Gynaecology College of Medicine and Health Science, School of Medicine, Debre Berhan University, Debre Berhan, Ethiopia.
Background: Non-adherence to antiretroviral therapy (ART) among pregnant women poses significant challenges to effective Immunodeficiency Virus (HIV) treatment outcomes and the promotion of maternal and infant health. This study identifies factors influencing ART non-adherence among HIV-positive pregnant women attending public health facilities in Dessie Town, Ethiopia.
Methods: A facility-based case-control study was conducted with 278 participants across health institutions in Dessie Town, comprising 208 controls and 70 cases.
Sci Rep
September 2025
Department of Electrical Engineering, Amirkabir University of Technology, Tehran, Iran.
Drug classification and target identification are crucial yet challenging steps in drug discovery. Existing methods often suffer from inefficiencies, overfitting, and limited scalability. Traditional approaches like support vector machines and XGBoost struggle to handle large, complex pharmaceutical datasets effectively.
View Article and Find Full Text PDF