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Despite the effectiveness of treating substance use disorders in primary care, access to such services remains limited. In this project, quality improvement methods were used to create and evaluate a rapid-access pathway for substance use treatment services in community health clinics. A "secret shopper" test gathered information about wait times and requirements. Results informed the development of a patient-centered pathway, in which patients requesting substance use treatment services were offered an immediate telehealth appointment with a provider and then linked to ongoing care services. This treatment pathway was feasible to implement, resulted in high treatment access rates, and was minimally disruptive to clinic operations.
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http://dx.doi.org/10.1176/appi.ps.20240150 | DOI Listing |
JMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.
Objectives: Azapirone-class drugs are partial 5-HT1A receptor agonists commonly used to treat anxiety disorders. Prior experimental studies have so far demonstrated that these drugs have low potential for dependence and problematic use and are considered safe treatment options compared with benzodiazepines. However, recent evidence suggesting the contrary raises concerns about their safety.
View Article and Find Full Text PDFObjectives: Cocaine use disorder (CUD) affects 1.4 million people in the United States, yet no FDA-approved treatments exist. In 2023, the Food and Drug Administration (FDA) released a draft guideline on treatments for stimulant use disorders, providing direction for trial design, outcomes, and population selection.
View Article and Find Full Text PDFMedComm (2020)
September 2025
The activation of nucleotide oligomerization domain-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome is implicated in the pathogenesis of various inflammatory diseases. The natural product oridonin possesses a novel mechanism for NLRP3 inhibition and a unique binding mode with NLRP3, but its poor anti-inflammatory activity limits further application. After virtual screening of diverse natural product libraries, dehydrocostus lactone (DCL) was considered as a potential NLRP3 inhibitor.
View Article and Find Full Text PDFSSM Qual Res Health
December 2025
Columbia University Mailman School of Public Health, Department of Sociomedical Sciences, United States.
Sex offender registration and notification (SORN) policies have significantly destabilizing material and psychosocial collateral consequences for people required to register. There are strong theoretical and anecdotal reasons to believe that SORN policies likely increase substance-use-related harms for registrants. However, no research has directly examined relationships between SORN policies and substance-use-related harms.
View Article and Find Full Text PDF