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Article Abstract
Genome mining of NBU2194 resulted in the identification of a family of 17-membered macrolides, neptunizhulides A-F. Their structures were elucidated by comprehensive spectroscopic data analysis. Stereochemical assignments of the neptunizhulides were determined by -based configuration analysis, ROESY NMR, Mosher's ester derivatization, and bioinformatic predictions. Bioinformatic analysis and a N-serine labeling experiment resulted in the identification of a putative -acyltransferase polyketide synthase (-AT PKS) biosynthetic gene cluster, and a biosynthetic pathway is proposed.
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| http://dx.doi.org/10.1021/acs.orglett.4c03801 | DOI Listing |
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