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Article Abstract
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832191 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2025.01.001 | DOI Listing |
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Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies.
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Article Synopsis
- Therapeutic vaccinations aim to prevent cancer by triggering immune responses against specific tumor-associated antigens (TAA) found in cancer cells.
- These vaccinations primarily focus on activating CD8 T lymphocytes, which play a crucial role in suppressing tumor growth by releasing cytokines.
- The review discusses how peptide-based vaccines enhance the production of important cytokines like IFN-γ, TNF-α, IL-2, and IL-12, and also examines the mechanisms of T cell activation and dysfunction.