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This study developed water-dispersible γ-oryzanol (WD-OZ) using a microemulsion system and assessed their absorption in rats. While OZ itself is hardly soluble in water, WD-OZ exhibited high water dispersibility, and OZ, along with its metabolites, was detected in rat plasma. These findings provide a solid basis for future application of the microemulsion-based approach to enhance the bioavailability of OZ in food.
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http://dx.doi.org/10.1093/bbb/zbaf002 | DOI Listing |
Crit Rev Anal Chem
September 2025
Department of Civil Engineering, Architecture and Engineering, Northeast Petroleum University, Daqing, China.
Surfactant is usually considered the key component to form microemulsion. surfactant-based microemulsion (SBME) can also be called traditional microemulsion. It has a wide range of applications.
View Article and Find Full Text PDFBiomacromolecules
September 2025
State Key Laboratory of Advanced Fiber Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China.
Development of efficient and stimuli-responsive gene delivery systems for therapeutic protein expression and immunomodulation remains challenging. Here, we report the synthesis of three types of pH-, reactive oxygen species (ROS)- and glutathione (GSH)-responsive dendrimer nanogels (for short, DNGs-pH, DNGs-ROS, and DNGs-GSH, respectively) a microemulsion method for delivery of messenger RNA (mRNA) and plasmid DNA (pDNA), both encoding enhanced green fluorescent protein (for short, mEGFP and pEGFP), to dendritic cells (DCs). The synthesized DNGs exhibit a nanoscale dimension, high monodispersity, desired colloidal stability, low cytotoxicity, and efficient gene delivery efficiency.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
Jinling Clinical Medical College, Nanjing University of Chinese Medicine, 305 East Zhongshan Road, Nanjing 210002, P.R. China.
Research on liposome-composite hydrogel microspheres (LHMs) drug delivery systems, primarily composed of drugs, liposomes, and hydrogels, has garnered growing scientific interest. LHMs exhibit biosafety, modifiability, a wide range of loaded drug categories (water-soluble or fat-soluble), controlled and sustainable drug release capability, and specific cell-targeted performance, which compensate for the shortcomings of conventional drug delivery methods due to the complementary advantages of liposome and hydrogel microspheres. In this review, we systematically analyze the existing literature on LHMs and provide a comprehensive overview of their preparation methods.
View Article and Find Full Text PDFYakugaku Zasshi
August 2025
Graduate School of Pharmaceutical Sciences, Chiba University.
Understanding the molecular-level properties of pharmaceutical formulations is essential for optimizing drug dissolution, stability, and delivery performance. In recent years, the structural complexity of formulations has increased significantly, incorporating multiple functional excipients. In this context, NMR spectroscopy has emerged as a powerful tool for evaluating the physicochemical behavior of active pharmaceutical ingredients (APIs) and excipients across diverse formulation platforms.
View Article and Find Full Text PDFPhysiol Res
August 2025
College of Dental Medicine, Western University of Health Sciences, Pomona, CA 91766-1854, USA.
This review summarizes the application of platelet membrane-coated biomimetic drug delivery systems in the treatment of various ischemia-reperfusion injuries (I/RI). Platelet membrane-coated nanoparticles, extracellular vesicles, microbubbles, microemulsions, as well as platelet membrane vesicles and their derivatives have shown significant promise for I/RI treatment. By leveraging the specific targeting, adhesive, and immune evasion properties of platelets, these systems enable the targeted delivery of therapeutic agents, such as antioxidants, anti-inflammatory agents, thrombolytics, and neuroprotective compounds, to ischemic tissues, while also offering diagnostic capabilities.
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