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Our study explores the potential relationship between infant feeding practices and settlement complexity in the Roman Empire through high-resolution Bayesian-modeled stable isotope measurements from incremental dentine. We compiled isotopic data from permanent first molars of individuals from various Roman sites: five from Bainesse (UK), 30 from Thessaloniki (Greece), along with new carbon and nitrogen isotope analyses from four individuals from Pompeii and six from Ostia Via del Mare (AVM). Our results reveal significant inter-site variability in breastfeeding durations, ranging from 1.5 years to approximately 5 years. Notably, individuals from the highly complex urban centers of Pompeii and Thessaloniki ceased breastfeeding around or below the 2-year weaning threshold recommended by Roman physicians. In contrast, individuals from the rural site of Ostia AVM and the site of Bainesse, near the northern frontier of the Roman Empire, generally ceased breastfeeding after 2 years of age. The link between settlement complexity and duration of breastfeeding observed in our study may have resulted from adherence to medical guidelines, support infrastructures, and/or strategies to mitigate financial constraints within households.
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http://dx.doi.org/10.1093/pnasnexus/pgae566 | DOI Listing |
Anaesthesia
September 2025
Department of Applied Health Sciences, School of Health Sciences, University of Birmingham, UK.
Introduction: Restoration of surgical capacity is essential to post-COVID-19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of health systems.
Methods: This is a secondary analysis of an international prospective cohort study of consecutive patients who underwent elective inguinal hernia surgery.
Risk Anal
September 2025
Edward J. Bloustein School, Rutgers University, New Brunswick, New Jersey, USA.
This AI-assisted review article offers a dual review: a book review of Living with Risk in the Late Roman World by Cam Grey, and a critical review of the current potential of large language models (LLMs), specifically ChatGPT's DeepResearch mode, to assist in thoughtful and scholarly book reviewing within risk science. Grey's book presents an innovative reconstruction of how communities in the late Roman Empire perceived and adapted to chronic environmental and societal risks, emphasizing spatial variability, cultural interpretation, and the normalization of uncertainty. Drawing on commentary from a human reviewer and a parallel AI-assisted analysis, we compare the distinct strengths and limitations of each approach.
View Article and Find Full Text PDFInt J Obes (Lond)
September 2025
Endocrinology, University Hospitals, Leuven, Belgium.
Background: Insufficient weight loss or weight regain after metabolic and bariatric surgery (MBS) is frequent, and evidence to support the use of pharmacotherapy for weight management is limited.
Methods: In this single-centre retrospective cohort study, the effectiveness of naltrexone/bupropion (NB) for weight control in surgery-naive and post-MBS patients was evaluated. Data was collected between 2016 and 2022 on all patients started on NB after multidisciplinary consult.
Sci Rep
September 2025
Acacia Lab for Implementation Science, School of Health Management, Southern Medical University, Guangzhou, China.
Health literacy is crucial for influencing health behaviors and outcomes; however, its development in China has been hindered by the lack of effective measurement tools and conceptual models. This study aimed to evaluate health literacy among Chinese residents using the HLS-Q47 and construct a health literacy model. A cross-sectional survey was conducted in Guangzhou from February to June 2023 involving 4047 participants.
View Article and Find Full Text PDFMedicina (Kaunas)
July 2025
Department of Diabetes and Nutrition Diseases, "Iuliu Hațieganu" University of Medicine and Pharmacy, 2-4 Clinicilor St., 400006 Cluj-Napoca, Romania.
: Type 2 diabetes (T2D) is a global health burden with increasing prevalence, necessitating effective management strategies. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as beneficial therapies, promoting both glycemic control and weight loss, yet real-world data on sex differences in response are limited. This study aimed to investigate sex-based differences in glycemic and weight outcomes, as well as adverse effects, in T2D patients treated with GLP-1 RAs at a single diabetes center.
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