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Article Abstract
Dual activation of the TLR7 and TLR8 pathways leads to the production of type I interferon and proinflammatory cytokines, resulting in efficient antigen presentation by dendritic cells to promote T-cell priming and antitumor immunity. We developed a novel series of TLR7/8 dual agonists with varying ratios of TLR7 and TLR8 activity for use as payloads for an antibody-drug conjugate approach. The agonist-induced production of several cytokines in human whole blood confirmed their functional activity. Structure-activity relationship studies guided by structure-based drug design are described.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726388 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.4c00463 | DOI Listing |
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