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http://dx.doi.org/10.1016/j.ekir.2024.11.003 | DOI Listing |
J Relig Health
September 2025
Center for Climate Action and Social Transformations (4CAST) Institute of Psychology, SWPS University, Warsaw, Poland.
The present study examined responses to COVID-19 at the beginning of the pandemic, April 2020, among a representative sample of 880 Poles. Participants described their religious beliefs, their emotional reactions to the pandemic, the changes they had made in their behavior since the onset of the pandemic, and their political orientation (left-right). Roman Catholics felt more threatened by the pandemic than non-believers, and Catholics reacted more strongly to the pandemic than non-believers in terms of feeling scared, paralyzed by fear, panicked, fearful, sad, woebegone, and lost, whereas there were no such differences on other emotional reactions.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
Department of Laboratory Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. Electronic address:
Prototheca, a genus of opportunistic pathogenic microalgae, can cause protothecosis in humans and animals, manifesting as cutaneous lesions or disseminated/systemic infections. This report describes a rare case of Prototheca wickerhamii toe infection in a 78-year-old Chinese male, presenting initially as gouty arthritis. The patient, who worked in fish farming with frequent water exposure, had a history of herpes zoster and hypertension.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China; Institute of Cell The
Despite its potential as a cancer immunotherapy, wild-type IL-2 is limited by dose-limiting toxicities, including vascular leak syndrome, and its strong activation of regulatory T cells (Tregs), which dampens anti-tumor immunity. These drawbacks are largely driven by IL-2's binding to IL-2Rα, and avoiding this interaction can reduce IL-2-associated toxicities, although it cannot completely eliminate them. To overcome these limitations, βγ-biased IL-2 variants (Non-α-IL-2) have been developed to selectively activate effector T and NK cells.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Institutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, Shanxi Province, China. Electronic address:
Butyrate is a short-chain fatty acid produced by intestinal bacteria during the fermentation of dietary fibers and has shown potential in modulating inflammatory responses. Herein, we investigated how sodium butyrate exerts dual, dose-dependent regulation of innate immunity using the zebrafish model of lipopolysaccharide (LPS)-induced inflammation. Our results demonstrated that at low concentrations (3 mM), sodium butyrate suppressed LPS-driven pro-inflammatory mediators (il1β, cebpβ, irg1l) while restoring anti-inflammatory and tissue-repair genes (lyz, il8, elf3).
View Article and Find Full Text PDFBiotechnol Bioeng
September 2025
BG Bioprocess Consulting Ltd, Palmerston North, New Zealand.
Polyphosphate (polyP) synthesis is ubiquitous in organisms, including microorganisms such as microalgae and yeasts, playing a crucial role in phosphorus (P) metabolism (e.g., storage) and in other vital functions.
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