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Introduction: Disorders of gut-brain interaction, such as functional dyspepsia (FD), are prevalent and challenging conditions. In other gastrointestinal (GI) disorders, individuals from underserved areas (UAs) have difficulty accessing care. Little is known about UA FD patient perspectives of their care, especially in those with limited English proficiency. We aimed to characterize patients' experiences with FD management with the goal of informing future studies targeting disorders of gut-brain interaction management in potentially vulnerable communities residing in UAs.
Methods: Participants meeting FD criteria were identified in 2 community health centers affiliated with a large academic medical center in the Northeastern United States. Semistructured interviews were conducted in English and Spanish. Transcripts were reviewed by a bilingual panel of investigators using the constant comparative method of iterative data acquisition. Psychosocial stressors and GI symptom severity were assessed.
Results: A total of 26 participants were interviewed (12 English-speaking and 14 Spanish-speaking). Broadly, GI symptoms were mild and there was mild-to-moderate psychological distress present. Adverse social determinants of health were highly prevalent. Despite mild symptom severity on objective scales, FD severely affected quality of life and interfered with physical, psychological, and social well-being, including avoidance of certain foods and professional/social situations. Study participants (particularly those with limited English proficiency status) reported difficulty in receiving care. Thematic saturation was achieved.
Discussion: Even when symptoms were mild, interviewees from UAs reported significant FD-related impairment, along with psychological distress. Education interventions targeting FD-related care in UAs should be designed to improve shared decision making in FD, sensitive to the burden of social determinants of health.
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http://dx.doi.org/10.14309/ctg.0000000000000817 | DOI Listing |
Fr J Urol
September 2025
Department of urology, Maison de Santé Protestante de Bordeaux-Bagatelle, Talence, France; Department of urology, HIA Robert-Picqué, Villenave d'Ornon, France.
Objectives: To evaluate the efficacy and safety of oral phosphodiesterase-5 inhibitors (PDE5Is) in the treatment of erectile dysfunction (ED). Additionally, to compare various PDE5Is and assess their suitability for different patient populations.
Evidence Acquisition: A systematic review of literature published from January 1999 to January 2023 was conducted following the PICOS criteria.
Gastroenterology
August 2025
Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, UK; Academic Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, UK. Electronic address:
Background & Aims: Individuals with disorders of gut-brain interaction (DGBI) may experience avoidant/restrictive food intake disorder (ARFID) symptoms. However, extant findings have been limited to specialist neurogastroenterology clinics. We assessed the association between DGBI and ARFID within the adult general population.
View Article and Find Full Text PDFInt J Surg
September 2025
Division of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: Functional dyspepsia (FD) is often comorbid with sleep disturbance. Transcutaneous auricular vagal nerve stimulation (taVNS) is a new and non-invasive therapeutic option. This study aimed to investigate its effects and possible mechanisms on FD with sleep disturbance.
View Article and Find Full Text PDFFront Nutr
August 2025
Department of Rehabilitation, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The pathogenesis of functional dyspepsia (FD) is closely associated with intestinal microecological alterations. Dietary microorganisms, capable of modulating gut microecology and thereby influencing gastrointestinal function, are being explored as a promising therapeutic strategy against FD. However, the precise mechanisms underlying how dietary microbes exert beneficial effects through microecological modulation, along with therapeutic protocols, remain incompletely defined.
View Article and Find Full Text PDFIntern Med
September 2025
Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Japan.
Objective Specific microRNAs (miRNAs) in patients with functional dyspepsia (FD) and previous Helicobacter pylori (HP) infections have not been elucidated. This study aimed to investigate exosomal miRNAs as potential biomarkers of FD in patients with a previous HP infection using a liquid biopsy. Methods Six patients with FD and six age- and sex-matched healthy controls (HCs) with a previous HP infection were enrolled in the discovery cohort.
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