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The urgent etiological diagnosis represents the main management objective of cervical spondylodiscitis (CSD) to start as soon as possible antibiotic treatment to prevent neurological deterioration. The present study aimed to evaluate a multicenter experience implementing a minimally invasive surgical approach (MISA) to manage CSD such pathology vs the most complex and aggressive surgical strategies currently used.This retrospective multicenter study used a database of 70 patients from five European neurosurgical centers. Patients with primary CSD underwent MISA via a limited funnel shaped cervical microdiscectomy with 4-mm anterior and 6-mm posterior longitudinal ligaments incision, PUS drainage, and extensive washing of the interbody and epidural space without fusion. Diagnosis was confirmed by clinical, imaging, laboratory, and perioperative histopathology and bacteriology.Of the 70 patients, 41 were men (58,5%), with an average age of 47.67 years. Severe neck pain affected 45 patients, while 51 had single-level cervical spondylodiscitis, 14 had double-level, and 5 had triple-level involvement. Staphylococcus aureus was identified in 49 cases. Each patient received a mean of three months of antibiotics. Inflammatory markers (C-reactive protein) were moderate for four weeks, then normalized by 8-12 weeks, except in one recurrence. After an average 48-month follow-up, all patients fully recovered without neurological deficit, spinal instability, or kyphotic deformity. Radiological exams confirmed bony fusion, with no recurrences of infection. MISA treatment offers a valuable, stable, and less invasive option for treating CSD, effectively identifying causative microorganisms and decompressing the spinal cord, leading to excellent patient outcomes.
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http://dx.doi.org/10.1007/s10143-025-03191-z | DOI Listing |
BMC Musculoskelet Disord
September 2025
Department of Orthopaedic and Trauma Surgery, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, Düsseldorf, 40225, Germany.
Background: The significance of native Computer tomography (CT) Scans as an alternative diagnostic tool beside Magnetic Resonance Imaging (MRI) for spondylodiscitis is poor according to the current data. CT Scans are currently reserved to analyze the bony destruction and for settings in which performing an MRI is contraindicated. Therefore, the aim of this study was to investigate, whether spondylodiscitis leads to a significant pattern of the density distribution from the affected vertebral bodies and discs measured by Hounsfield Units (HU) in native CT Scans.
View Article and Find Full Text PDFCureus
July 2025
Internal Medicine, Universidad Iberoamericana, Mexico City, MEX.
Osteomyelitis is an infection of the bone tissue, causing inflammation. Common causes and risk factors include trauma, surgical procedures, the presence of foreign bodies, and immunocompromised states such as Human Immunodeficiency Virus (HIV) infection and diabetes mellitus. Osteomyelitis occurring in the absence of risk factors is relatively rare.
View Article and Find Full Text PDFReports (MDPI)
August 2025
Ng Teng Fong General Hospital, Singapore 609606, Singapore.
In this report of two cases, we describe two patients with spinal involvement of gout. The first case involved a 67-year-old female who presented to the emergency department with a one-week history of weakness in both the upper and lower limbs, despite no prior history of gout. Cervical spine MRI revealed spinal cord compression at the C4 level from a posterior lesion.
View Article and Find Full Text PDFCureus
July 2025
Department of Internal Medicine, University of Arizona College of Medicine - Tucson, Tucson, USA.
Coccidioidomycosis, also known as "Valley Fever," is an endemic fungal infection caused by species, typically presenting as a respiratory illness. Disseminated disease, particularly with extensive skeletal involvement, is rare and typically seen in immunocompromised individuals. We report a unique and severe case of disseminated musculoskeletal coccidioidomycosis in a previously healthy immunocompetent 33-year-old African American man, involving multiple spinal levels, pelvic bones, and the right chest wall.
View Article and Find Full Text PDFSpine J
July 2025
Norton Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, KY 40202, USA. Electronic address:
Background Context: Intravenous drug use (IVDU) is a significant risk factor for spinal infections. However, spinal infection in IVDU patients compared to Non-IVDU remains poorly described in the literature.
Purpose: To assess the characteristics, surgical outcomes, and complications of spinal infections in patients IVDU and Non-IVDU patients.