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Background: The rapid proliferation of artificial intelligence (AI) requires new approaches for human-AI interfaces that are different from classic human-computer interfaces. In developing a system that is conducive to the analysis and use of health big data (HBD), reflecting the empirical characteristics of users who have performed HBD analysis is the most crucial aspect to consider. Recently, human-centered design methodology, a field of user-centered design, has been expanded and is used not only to develop types of products but also technologies and services.
Objective: This study was conducted to integrate and analyze users' experiences along the HBD analysis journey using the human-centered design methodology and reflect them in the development of AI agents that support future HBD analysis. This research aims to help accelerate the development of novel human-AI interfaces for AI agents that support the analysis and use of HBD, which will be urgently needed in the near future.
Methods: Using human-centered design methodology, we collected data through shadowing and in-depth interviews with 16 people with experience in analyzing and using HBD. We identified users' empirical characteristics, emotions, pain points, and needs related to HBD analysis and use and created personas and journey maps.
Results: The general characteristics of participants (n=16) were as follows: the majority were in their 40s (n=6, 38%) and held a PhD degree (n=10, 63%). Professors (n=7, 44%) and health care personnel (n=10, 63%) represented the largest professional groups. Participants' experiences with big data analysis varied, with 25% (n=4) being beginners and 38% (n=6) having extensive experience. Common analysis methods included statistical analysis (n=7, 44%) and data mining (n=6, 38%). Qualitative findings from shadowing and in-depth interviews revealed key challenges: lack of knowledge on using analytical solutions, crisis management difficulties during errors, and inadequate understanding of health care data and clinical decision-making, especially among non-health care professionals. Three types of personas and journey maps-health care professionals as big data analysis beginners, health care professionals who have experience in big data analytics, and non-health care professionals who are experts in big data analytics-were derived. They showed a need for personalized platforms tailored to the user level, appropriate direction through a navigation function, a crisis management support system, communication and sharing among users, and expert linkage service.
Conclusions: The knowledge obtained from this study can be leveraged in designing an AI agent to support future HBD analysis and use. This is expected to further increase the usability of HBD by helping users perform effective use of HBD more easily.
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http://dx.doi.org/10.2196/67272 | DOI Listing |
Research (Wash D C)
September 2025
NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan 571199, China.
Aging is characterized by a gradual decline in the functionality of all the organs and tissues, leading to various diseases. As the global population ages, the urgency to develop effective anti-aging strategies becomes increasingly critical due to the growing severity of associated health problems. Immunotherapy offers novel and promising approaches to combat aging by utilizing approaches including vaccines, antibodies, and cytokines to target specific aging-related molecules and pathways.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.
Introduction: Human papillomavirus (HPV) infection has been implicated in autoimmune processes, yet concerns remain about the potential autoimmune risks of HPV vaccination. Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition that typically manifests in childhood. The relationship between HPV vaccination and the development of JIA remains uncertain.
View Article and Find Full Text PDFNat Sci Sleep
September 2025
Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People's Republic of China.
Objective: To investigate the prevalence of dry eye disease (DED) among children and adolescents aged 9 to 19 years in Fengyang County, and to explore the associations of sleep duration and social jetlag with DED, with the aim of providing scientific evidence for sleep-based interventions to prevent DED in this population.
Methods: Between November and December 2023, 14 primary and secondary schools were randomly selected in Fengyang County, Chuzhou City, Anhui Province, China. Students from Grade 4 to Grade 12 (aged 9-19 years) were invited to participate.
Front Genet
August 2025
Hunan Provincial Key Laboratory of Finance and Economics Big Data Science and Technology, Hunan University of Finance and Economics, Changsha, China.
RNA N4-acetylcytidine (ac4C) is a crucial chemical modification involved in various biological processes, influencing RNA properties and functions. Accurate prediction of RNA ac4C sites is essential for understanding the roles of RNA molecules in gene expression and cellular regulation. While existing methods have made progress in ac4C site prediction, they still struggle with limited accuracy and generalization.
View Article and Find Full Text PDFFront Big Data
August 2025
MaiNLP, Center for Information and Language Processing, LMU Munich, Munich, Germany.
Predicting career trajectories is a complex yet impactful task, offering significant benefits for personalized career counseling, recruitment optimization, and workforce planning. However, effective career path prediction (CPP) modeling faces challenges including highly variable career trajectories, free-text resume data, and limited publicly available benchmark datasets. In this study, we present a comprehensive comparative evaluation of CPP models-linear projection, multilayer perceptron (MLP), LSTM, and large language models (LLMs)-across multiple input settings and two recently introduced public datasets.
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