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http://dx.doi.org/10.1007/s11695-024-07656-w | DOI Listing |
J Eval Clin Pract
September 2025
Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan.
Rationale: Physicians sometimes encounter various types of gut feelings (GFs) during clinical diagnosis. The type of GF addressed in this paper refers to the intuitive sense that the generated hypothesis might be incorrect. An appropriate diagnosis cannot be obtained unless these GFs are articulated and inventive solutions are devised.
View Article and Find Full Text PDFJ Pathol Transl Med
September 2025
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Background: This study aimed to reclassify a subset of poorly differentiated salivary gland carcinoma that do not conform to any entities of the current World Health Organization (WHO) classification into the category of undifferentiated carcinoma (UDC) because they lack specific histologic differentiation or immunophenotype.
Methods: Cases of salivary gland carcinomas from Asan Medical Center (2002-2020) that did not fit any existing WHO classification criteria and were diagnosed as poorly differentiated carcinoma, high-grade carcinoma, or UDC, were retrospectively reviewed. Immunohistochemical (IHC) staining for p40, neuroendocrine markers, androgen receptor (AR), and gross cystic disease fluid protein 15 (GCDFP-15) and Epstein-Barr virus (EBV) in situ hybridization (ISH) were performed.
Cell Physiol Biochem
September 2025
Department of Histology and Embryology and Vascular Biology Student Research Club, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland, E-Mail:
Migrasomes are newly discovered, migration-dependent organelles that mediate the release of cellular contents into the extracellular environment through a process known as migracytosis. Since their identification in 2014, growing evidence has highlighted their critical roles in intercellular communication, organ development, mitochondrial quality control, and disease pathogenesis. Migrasome biogenesis is a complex, multi-step process tightly regulated by lipid composition, tetraspanin-enriched microdomains, and molecular pathways involving sphingomyelin synthase 2, Rab35, and integrins.
View Article and Find Full Text PDFInorg Chem
September 2025
Department of Chemistry and Chemical Engineering, Heze University, Heze, Shandong 274015, China.
Transition metal (TM)-doped silicon clusters represent critical model systems for understanding nanoscale hybridization and stability mechanisms. This study provides a comprehensive analysis of structural evolution, electronic properties, and thermodynamic stability in ruthenium-doped silicon clusters (RuSi̅, = 7-11) through integrated experimental and computational approaches. Anion photoelectron spectroscopy combined with density functional theory (DFT/B3LYP), coupled-cluster theory [CCSD(T)], and bonding analyses (AdNDP, NICS, ACID) reveals charge-state-dependent structural transitions, with full Ru encapsulation emerging at = 10 for anions and = 11 for neutrals.
View Article and Find Full Text PDFEur J Prev Cardiol
September 2025
Department of Sport, Exercise and Health, Sports and Exercise Medicine, Medical Faculty, University of Basel, Basel, Switzerland.
The current guidelines for cardiovascular disease prevention by the European Society of Cardiology highlight the undisputable benefits of exercise and a physically active lifestyle for cardiovascular risk reduction. In addition to the health benefits of physical activity, observational data suggests that regular physical activity lowers all-cause mortality. However, this was not confirmed by Mendelian randomization studies and randomized controlled trials.
View Article and Find Full Text PDF