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Article Abstract
Integration of spatial transcriptomic (GeoMx Digital Spatial Profiler) and single-cell RNA sequencing data from multiple gastric cancers identifies spatially resolved expression-based intratumoral heterogeneity, associated with distinct immune microenvironments. We uncovered two separate evolutionary trajectories associated with specific molecular subtypes, clinical prognoses, stromal neighborhoods, and genetic drivers. Tumor-stroma interfaces emerged as a unique state of tumor ecology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962405 | PMC |
| http://dx.doi.org/10.1158/2159-8290.CD-24-0605 | DOI Listing |
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