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Background/objectives: The use of natural colourants is gaining attention due to their biocompatibility and functional benefits. This study introduces a different approach using turmeric ( L.) dye extract combined with chitosan to significantly enhance the antibacterial and UV-shielding properties of silk.
Methods: The turmeric dye's chemical composition was analyzed using liquid chromatography mass spectrometry (LC-MS), UV-visible spectroscopy, and Fourier-transform infrared spectroscopy (FTIR). The dyed silk's colourfastness was tested through rubbing, washing, and light exposure.
Results: The chitosan-mordanted silk showed strong antibacterial activity against () and (), as well as antifungal activity against (). It also demonstrated a high ultraviolet protection factor (UPF). For comparison, alum-mordant was used, and chitosan proved more effective. Beyond its use as a dye, turmeric is renowned for its medicinal properties. Its antioxidant, anticancer, and anti-inflammatory properties have been extensively researched, which are primarily linked to its curcuminoid compounds. Turmeric is used in traditional medication to treat digestive issues, arthritis, and skin diseases.
Conclusions: This work underscores the innovative use of plant-based dye extracts and natural mordants like chitosan as a sustainable alternative to conventional metallic mordants, paving the way for the evolution of bioactive silk with improved functional properties.
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http://dx.doi.org/10.3390/pharmaceutics16121510 | DOI Listing |
Int J Biol Macromol
September 2025
Department of Protein Science, Division of Protein Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden. Electronic address:
This paper presents the generation and evaluation of a novel potential drug delivery platform for biologics, based on recombinant spider silk. Targeting CD40 for activation of antigen presenting cells, in order to overcome tumor induced T cell tolerance, have shown promising results in cell and animal models. However, further trials have gained limited results due to severe side reactions.
View Article and Find Full Text PDFJ Extracell Vesicles
September 2025
Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Intervertebral disc degeneration (IVDD) is a common age-related disorder associated with inflammation, pain and impaired mobility. In this study, we developed a therapeutic system using silk fibroin (SF) hydrogel loaded with mRNA-engineered extracellular vesicles derived from murine bone marrow mesenchymal stem cells (BMSCs-EVs) to modulate macrophage polarization and alleviate IVDD. BMSCs were isolated from 6-week-old C57BL/6 mice, and an acute IVDD model was established via 18G needle puncture of the coccygeal discs (Co7-Co10).
View Article and Find Full Text PDFACS Omega
August 2025
State University of Campinas (UNICAMP), School of Chemical Engineering, Department of Materials and Bioprocess Engineering, Av Albert Einstein, 500, CEP 13083-852 Campinas, SP, Brazil.
Silk fibroin (SF) and mucin are extensively recognized as promising biomaterials for wound dressings due to their outstanding biocompatibility, biodegradability, and ability to support cell growth and tissue regeneration. In this study, we developed a hybrid SF/mucin wound dressing (HYB) using tetrazine and norbornene click chemistry to enhance its structural and functional properties. The robust assembly resulted in a dual-phase material with a dense SF membrane and a porous mucin hydrogel (MH).
View Article and Find Full Text PDFACS Nano
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511443, P. R. China.
The application of ferroptosis inducer FIN56 to decrease antioxidant levels in lung adenocarcinoma (LUAD) is a promising tumor eradication technique. However, several obstacles reduce the efficacy of ferroptosis therapy including insufficient oxidative stress from monotherapy and restricted drug retention in tumor tissues. To address these challenges, we developed an inhalable hybrid liposome in which FIN56 and piperlongumine (PPL) are coloaded into silk fibroin nanoparticles to overcome the limitation of the poor therapeutic effect of single-drug ferroptosis.
View Article and Find Full Text PDFInt J Biol Macromol
August 2025
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China; Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology, Ningbo Cixi Instit
Developing macroporous hydrogels with enhanced mechanical strength and favorable cell adhesion is crucial for effective cartilage repair. The freeze-thaw (FT) technique, a simple, environmentally friendly, and non-toxic approach, is widely employed to fabricate biocompatible macroporous hydrogels. In this study, a water-insoluble polyvinyl alcohol/silk fibroin (PVA/SF) porous cryogel was successfully fabricated via a cyclic FT process.
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