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In this issue of Molecular Cell, Gambi, Boccalatte, Hernaez, et al. apply multiomics followed by genetic engineering to define then characterize epigenetic hubs that regulate processes crucial for T-ALL and use this insight to offer new avenues for therapeutic targeting.
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http://dx.doi.org/10.1016/j.molcel.2024.12.011 | DOI Listing |
Front Immunol
September 2025
The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Super-enhancers (SEs) are dynamic chromatin structures that function as epigenetic hubs, orchestrating cell-type-specific transcriptional programs crucial for immune cell differentiation, functional specialization, and adaptive responses. These enhancer clusters integrate transcription factor (TF) networks, chromatin-modifying signals, and three-dimensional genome organization to govern lineage commitment, effector function acquisition, and metabolic reprogramming while enabling plasticity in response to environmental cues. SEs exhibit spatiotemporal regulatory properties, such as chromatin looping, phase-separated condensate formation, and stimulus-driven enhancer-promoter rewiring, all of which stabilize transcriptional outputs vital for immune homeostasis.
View Article and Find Full Text PDFPlant Physiol
August 2025
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Liquid-liquid phase separation (LLPS) has emerged as a crucial mechanism for transcriptional regulation in plants, enabling the dynamic compartmentalization of biomolecular condensates. These condensates orchestrate gene expression by modulating the spatiotemporal distribution of transcription factors, allowing plants to cope with fluctuating environments. Recent studies have revealed two distinct LLPS-driven modes in plants.
View Article and Find Full Text PDFSuper-enhancers (SEs) are clusters of enhancers with high transcriptional activity that play essential roles in defining cell identity through regulation of nearby genes. SEs preferentially form multiway chromatin interactions with other SEs and highly transcribed regions in embryonic stem cells. However, the properties of the interacting SEs and their specific contributions to complex regulatory interactions in differentiated cell types remain poorly understood.
View Article and Find Full Text PDFCrit Rev Oncol Hematol
August 2025
Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address:
Extrachromosomal DNA (ecDNA) is a large (typically >5 kb), functional, circular double-stranded DNA molecule that exists independently of chromosomes within the cell nucleus. Its widespread presence in human tumors and crucial role in tumorigenesis have garnered notable attention. Critically, in cancer, they often carry full-length oncogenes along with their regulatory elements.
View Article and Find Full Text PDFExp Hematol
August 2025
Department of Genetics, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany. Electronic address:
Transcription factor networks are critical hubs for organ development. Here, we investigated the hematopoietic function of the E-twenty six (Ets)-family transcription factor E74-like factor 1 (Elf1) that is normally predominantly expressed in monocytes. Strikingly, Elf1 was not only a direct downstream target of homeobox A9 (HoxA9) and leukemogenic mixed-lineage leukemia (MLL) fusion proteins but it was also consistently overexpressed in acute myeloid leukemia (AML) regardless of the underlying genotypic alteration.
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