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Article Abstract
A new 12-membered resorcylic acid lactone, cochliomycin H (), and one known resorcylic acid lactone, -demethylated-zeaenol (), were isolated from sponge-derived fungus sp. ZYX-Z-4. The structure of was elucidated by 1D and 2D NMR spectroscopic as well as HR-ESI-MS analysis. The configuration of was established by the NMR chemical shifts calculation followed by DP4+ analysis and ECD calculation. Compounds and were evaluated for the antifungal and neuroprotective activities and compound showed comparable neuroprotective effect on the HO injured SH-SY5Y cells to that of trolox.
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