Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Refeeding oedema, believed to result from the effects of insulin on renal sodium retention and subsequent oedema formation, typically occurs during the first 2 weeks after reintroduction of nutrition in individuals with severe malnutrition and can intensify body image distress in patients with eating disorders (EDs). Phosphate supplements have been found to increase insulin sensitivity, and it is hypothesised that they may also contribute to refeeding oedema in patients with EDs.
Method: In this retrospective cohort study of 633 patients with severe malnutrition due to anorexia nervosa (AN) or avoidant restrictive food intake disorder (ARFID), the impact of phosphate supplementation on the rate of weight gain was investigated.
Results: 39% of patients required treatment with phosphate supplements during their hospital course. Patients in the phosphate supplement group had significantly more weight gain than the cohort who did not receive a phosphate supplement (p < 0.05). The rate of weight gain also increased, in the phosphate supplement group, as admission body mass index decreased.
Conclusions: This is the first study to suggest that crucial phosphate supplementation contributes to refeeding oedema in patients with EDs. Future studies should seek to better understand the relationship between phosphate supplementation and weight trends in order to optimise clinical management.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/erv.3169 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Short-Term Calcifediol Supplementation on Leukocyte Cytokine Production in Healthy Dogs: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial.
J Vet Intern Med
September 2025
Department of Specialty Medicine, Midwestern University College of Veterinary Medicine, Glendale, Arizona, USA.
Background: Vitamin D modulates the immune response in many species, including dogs. To date, research investigating the immunological effects of vitamin D in dogs is limited to in vitro studies.
Objectives: Provide PO calcifediol supplementation to healthy dogs to evaluate its tolerability and assess its effect on leukocyte production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10.
Kartogenin-encapsulated self-healing injectable hydrogel based on hyaluronic acid and chitosan derivative for use as viscosupplementation in knee osteoarthritis.
Int J Biol Macromol
September 2025
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; Bioplastics Production Laboratory for Medical Applications, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Materials Science and Technology, Chiang Mai Univ
Early osteoarthritis treatment often relies on viscosupplementation via intra-articular injections, which are limited by inflammation risk and poor cartilage restoration. To address these issues, self-healing hydrogels provide a promising alternative because of their ability to recover structure after mechanical stress. This study reports an injectable self-healing hydrogel composed of N-succinyl chitosan (NSC) and hyaluronic dialdehyde (HAD), combined with kartogenin (KGN), synthesized under mild conditions via Schiff base reactions.
View Article and Find Full Text PDFSuccinylation regulates boar sperm linear motility via reprogramming glucose metabolism.
Commun Biol
August 2025
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Succinylation is a recently identified post-translational modification (PTM) that modulates enzyme activity and metabolism. However, how it regulates metabolic reprogramming in sperm remains unclear. In this study, we show that succinylation of pyruvate kinase M2 (PKM2) promotes oxidative phosphorylation (OXPHOS) and linear motility in boar sperm.
View Article and Find Full Text PDFExpression of fibroblast growth factor 23 (FGF23) and αKlotho in two commercial laying hen strains fed with and without dietary mineral P supplements before and after the onset of the laying phase.
Poult Sci
August 2025
Department of Physiology, University of Hohenheim, 70599 Stuttgart, Germany. Electronic address:
Maintenance of phosphate homeostasis is particularly critical in laying hens for bone formation and calcium mobilization. The supplementation of their feed with mineral phosphate is common although recent research questions the usual levels of supplementation. Phosphate homeostasis is classically regulated by active vitamin D (calcitriol) and parathyroid hormone, whereas fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho are novel factors.
View Article and Find Full Text PDFPseudohypoparathyroidism with normocalcemia: a rare case report from Nepal.
Ann Med Surg (Lond)
July 2025
Department of Internal Medicine, Tribhuvan University, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Introduction: Pseudohypoparathyroidism (PHP), a rare genetic disorder is characterized by features of hypoparathyroidism due to tissue resistance to effect of parathyroid hormone (PTH).
Case Presentation: A 1-year-old girl, the first child of healthy non-consanguineous parents with no family history of similar conditions or skeletal deformities, presented with small bumps on her leg, wrist, and periumbilical region for 6 months. Lab results revealed high serum phosphate, low vitamin D, normal calcium, and elevated PTH levels.