Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Recognition memory, an essential component of cognitive health, can suffer from biological limitations of stress, aging, or neurodegenerative disease. Vagus nerve stimulation (VNS) is a neuromodulation therapy with the potential to improve cognitive function. This study investigated the effectiveness of multiple sessions of VNS to enhance recognition memory in healthy rodents and the underlying cognitive benefits of VNS by proteomic analysis of the synaptosome.
Methods: Rats demonstrated VNS-induced recognition memory improvements using a novel object recognition (NOR) task. Using the LC-MS/MS method, roughly 3,000 proteins in the synaptosome of the hippocampus were analyzed.
Results: Protein-protein interaction (PPI) enrichment analysis found differentially expressed proteins related to synaptic signaling and neurotransmitter pathways. PPI network analysis identified six unique protein clusters, including a cluster of synaptic signaling related pathways. Using ingenuity pathway analysis (IPA), rapamycin-insensitive companion of mTOR was identified as an upstream regulator of synaptosome changes due to VNS-paired training.
Discussion: Based on these results, it is proposed that VNS may mediate cognitive enhancement via increases in glutamatergic signaling and early LTP during the consolidation period, followed by sustained synaptic plasticity via modified post-synaptic receptor expression and dendritic outgrowth. Further investigation is required to determine if VNS is a good candidate to ameliorate cognitive impairment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685747 | PMC |
| http://dx.doi.org/10.3389/fnmol.2024.1452327 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia.
Metab Brain Dis
September 2025
Department of Neuroscience, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Brain ischemia is a major global cause of disability, frequently leading to psychoneurological issues. This study investigates the effects of 4-aminopyridine (4-AP) on anxiety, cognitive impairment, and potential underlying mechanisms in a mouse model of medial prefrontal cortex (mPFC) ischemia. Mice with mPFC ischemia were treated with normal saline (NS) or different doses of 4-AP (250, 500, and 1000 µg/kg) for 14 consecutive days.
View Article and Find Full Text PDFTeachers' experiences of supporting the mental health needs of refugee students in resource-poor settings: a qualitative study in Iran.
Eur J Psychotraumatol
December 2025
Department of Psychology, University of Bath, Bath, UK.
Exposure to traumatic events is common amongst children from refugee backgrounds. Given the restricted access of refugee children to formal specialist resources and disrupted parental support mechanisms in low- and middle-income countries (LMICs), teachers are increasingly expected to be the primary responders to the complex psychosocial needs of trauma-exposed refugee children. However, despite LMICs hosting over two-thirds of the world's refugee children, our current knowledge of how teachers respond to these needs is predominantly drawn from studies conducted in well-resourced, high-income countries, which fails to capture the unique experiences of teachers in inadequately resourced schools in LMICs.
View Article and Find Full Text PDFBinocular cues to 3D face structure increase activation in depth-selective visual cortex with negligible effects in face-selective areas.
J Vis
September 2025
Neuroscience Program, Western University, London, ON, Canada.
Studies of visual face processing often use flat images as proxies for real faces due to their ease of manipulation and experimental control. Although flat images capture many features of a face, they lack the rich three-dimensional (3D) structural information available when binocularly viewing real faces (e.g.
View Article and Find Full Text PDFChange, continuity, and decision-making in the transition to old-age retirement from work and day activity services: qualitative longitudinal follow-up.
Int J Qual Stud Health Well-being
December 2025
Department of Social Sciences, Tampere University, Tampere, Finland.
Purpose: To increase understanding of the transition from work and day activity services to old-age retirement among people with intellectual disabilities. The research questions are as follows: 1) How are change and continuity present in the transitions to old-age retirement of older people with an intellectual disability? 2) What is the role of the person's own decision-making in the transition process?
Methods: A longitudinal case study approach was used. The main data consist of qualitative interviews from a one-year period with four people with an intellectual disability aged 59-65.
Optically Controlled Memristor Enabling Synergistic Sensing-Memory-Computing for Neuromorphic Vision Systems.
Adv Mater
September 2025
Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province, College of Electronic and Information Engineering, Hebei University, Baoding, 071002, China.
Neuromorphic Visual Devices hold considerable promise for integration into neuromorphic vision systems that combine sensing, memory, and computing. This potential arises from their synergistic benefits in optical signal detection and neuro-inspired computational processes. However, current devices face challenges such as insufficient light/dark resistance ratios, mismatched transient photo-response, and volatile retention characteristics, limiting their adaptability to complex artificial vision systems.
View Article and Find Full Text PDF