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Article Abstract
In a previous study, we reported that nilotinib, a BCR-ABL tyrosine kinase inhibitor, possesses moderate antimalarial activity against PfK1 and PfFCR3. As a part of our efforts to develop novel antimalarial agents, a series of novel triazine analogs was identified as potent antimalarial agents via structure modification of nilotinib. Compound 15a showed strong antimalarial activities against PfK1 and PfFCR3 with IC values of 0.28 and 0.29 µM, respectively.
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| http://dx.doi.org/10.1016/j.bmcl.2024.130091 | DOI Listing |
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