Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Modeling aerosol dynamics in the airways is challenging, and most modern personalized tools consider only a single inhalation maneuver through less than 10% of the total lung volume. Here, we present an modeling pipeline to produce a device that preserves patient-specific upper airways while approximating deeper airways, capable of achieving total lung volumes over 7 liters. The modular system, called TIDAL, includes tunable inhalation and exhalation breathing capabilities with resting flow rates up to 30 liters per minute. We show that the TIDAL system is easily coupled with industrially and clinically relevant devices for aerosol therapeutics. Using a vibrating mesh nebulizer, we report central-to-peripheral (C:P) aerosol deposition measurements aligned with both and benchmarks. These findings underscore the effectiveness of the TIDAL model in predicting airway deposition dynamics for inhalable therapeutics.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671099 | PMC |
| http://dx.doi.org/10.1016/j.device.2024.100514 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Urban pollution impact assessment in six lithuanian cities with a focus on road traffic emissions - integrated framework for environmental health studies.
J Hazard Mater
September 2025
Private Researcher, Kupiškis, Lithuania.
An integrated framework is introduced and applied to assess the health impact of airborne pollution with greater physiological relevance, moving beyond conventional exposure metrics. Measured particle number size distribution data was integrated with a regional respiratory tract deposition fractions to estimate total and alveolar deposited particle surface area concentrations. Land use regression modeling, combined with randomized commuting patterns, enabled the evaluation of city-specific alveolar surface area deposition doses, providing new insight into localized average exposure and its implications for public health.
View Article and Find Full Text PDFBouncing microdroplets on hydrophobic surfaces.
Proc Natl Acad Sci U S A
September 2025
TCM Group, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0US, United Kingdom.
Intuitively, slow droplets stick to a surface and faster droplets splash or bounce. However, recent work suggests that on nonwetting surfaces, whether microdroplets stick or bounce depends only on their size and fluid properties, but not on the incoming velocity. Here, we show using theory and experiments that even poorly wetting surfaces have a velocity-dependent criterion for bouncing of aqueous droplets, which is as high as 6 m/s for diameters of 30 to 50 [Formula: see text]m on hydrophobic surfaces such as Teflon.
View Article and Find Full Text PDFCommunity Composition of Microbial Eukaryotes Transported by Stemflow from Fagus grandifolia Ehrh. (American Beech) Trees in Northeastern Ohio (USA).
Microb Ecol
September 2025
Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH, 44115, USA.
Stemflow, the concentrated fraction of rainfall that drains down tree trunks, can translocate canopy biota to the forest floor, but its eukaryotic composition remains uncharacterized via eDNA methods. We collected stemflow from 18 Fagus grandifolia (American beech) trees during ten storms in northeastern Ohio (USA) and analyzed 18S rRNA eDNA to resolve transported microbial-eukaryote communities. Over 12 million reads (83 samples) revealed 920 zero-radius OTUs spanning fungi, algae, protists, and metazoans.
View Article and Find Full Text PDFModels of Surfactant Replacement Therapy in Neonatal Lungs.
J Biomech Eng
September 2025
Department of Biomedical Engineering, The University of Akron, 244 Sumner Street Akron, OH 44325.
The lungs play a critical role in gas exchange and overall respiratory functions, relying on a delicate balance of pulmonary mechanics and surfactant homeostasis. Surfactant replacement therapy (SRT) is a life-saving intervention for conditions such as neonatal respiratory distress syndrome (NRDS), where surfactant deficiency impairs alveolar stability and normal gas exchange. To improve treatment strategies of lung disorders such as NRDS, researchers have developed a variety of computational, benchtop, and animal models to investigate surfactant transport and drug delivery in the lungs.
View Article and Find Full Text PDFBalancing efficacy and portability: comparative / evaluation of MDI PLUS® versus AeroChamber2go™ spacers for aerosol delivery.
J Asthma
September 2025
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-suef University, Beni-suef, Egypt.
Background: The Global Initiative for Asthma (GINA) recommended using spacers or valved holding chambers to counter the common problems of poor pressurized metered dose inhaler (pMDI) technique. However, many subjects avoid using conventional spacers because they are bulky and inconvenient to carry around in public.
Objective: We aimed to compare the novel, MDI PLUS spacer, with AeroChamber2go™ on their and aerosol performance, as well as their user training requirements.