Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Bisindole alkaloids constitute a significant class of natural compounds distinguished by their characteristic bisindole structure and renowned for their anticancer properties. Over the last six decades, researchers have isolated 425 microorganism-derived bisindole alkaloids (MDBAs). Among them, 187 MDBAs have demonstrated anticancer properties against various in vitro cancer cell lines, primarily by impeding the cell cycle, restraining cell proliferation, and inducing apoptosis and autophagy. These effects are mediated by regulating key targets and signaling pathways such as hypoxia-inducible factor (HIF)-1, MAPK, and phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR. This review provides a comprehensive examination of the sources, chemical diversity, and anticancer properties of these compounds. Furthermore, it summarizes the structure-activity relationship (SAR), druggability, and the mechanisms underlying MDBAs' anticancer effects. Ultimately, this article aims to furnish a thorough overview of the advancements in the investigation of microorganism-derived bisindole alkaloids for their continued development and utilization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.202402398 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus.
Plant Biotechnol J
September 2025
Frontiers Science Center for Transformative Molecules, Joint International Research Laboratory of Metabolic & Developmental Sciences, Plant Biotechnology Research Center, SJTU-Fudan-Nottingham Plant Biotechnology R&D Center, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai,
Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine. However, the regulatory mechanisms underlying this process are not yet fully understood.
View Article and Find Full Text PDFCaulerpin suppresses tumor-associated angiogenesis and tumor growth via Hippo signaling in cervical cancer.
Toxicol Appl Pharmacol
September 2025
Department of Pathology, Jinan University School of Medicine, Guangzhou, China. Electronic address:
Caulerpin, a bisindole alkaloid derived from green algae of the genus Caulerpa, has exhibited a promising anti-proliferative effect on various tumor cells in vitro. However, its pharmacological potential has not been intensively explored in cervical cancer. In this study, the antitumor property of caulerpin was assessed in cervical cancer cells (HeLa and SiHa cells) and xenograft mouse models.
View Article and Find Full Text PDFMonoterpene Indole Alkaloids with Antimicrobial Activity Against .
Int J Mol Sci
August 2025
BioISI-Instituto de Biossistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
infection, a leading cause of gastric ulcers and gastric cancer, presents a major health challenge, exacerbated by rising antibiotic resistance. This study investigated the antibacterial potential of plant-derived compounds, isolated from different plant species, against . Thus, a library of 153 natural compounds and derivatives, including monoterpene indole and bisindole alkaloids, obtained from the African medicinal plant was screened in vitro for minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against .
View Article and Find Full Text PDFRapid construction of bisindole alkaloids caulersin and racemosin B from methyl 3-indolylpyruvate based on a biomimetic dimerization strategy.
Org Biomol Chem
August 2025
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China.
Attempts to directly construct bisindole alkaloids caulerpin and caulersin resulted in the discovery of novel synthetic approaches to a specific bisindole framework with a central troponoid core and an unexpected product-racemosin B. The developed biomimetic domino sequences were triggered by a dimerization process from a shared precursor, methyl 3-indolylpyruvate. Thus, caulersin and racemosin B could be produced in 1 and 2 step processes.
View Article and Find Full Text PDFEnhancing indirubin biosynthesis in Escherichia coli by engineering Methylophaga aminisulfidivorans favin-containing monooxygenase.
Int J Biol Macromol
August 2025
State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Indirubin, a naturally occurring bisindole alkaloid, has demonstrated clinical efficacy in the management of chronic myeloid leukemia while exhibiting multiple pharmacological activities including antitumor, anti-inflammatory, and broad-spectrum antibacterial effects. To enhance indirubin biosynthesis in the engineered Escherichia coli BL21 (DE3) host, an integrated metabolic engineering strategy was systematically executed in a sequential manner. Firstly, the Methylophaga aminisulfidivorans flavin-containing monooxygenase (MaFMO) was heterologously overexpressed under the regulation of the strong P promoter.
View Article and Find Full Text PDF