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Recently unearthed Tinhui Medical Slips, dating back to 2nd century BCE, demonstrates the 12th meridian in Chinese medicine as an anatomy-based discovery. This is equivalent to the persistent median artery, which was later incorporated into Neijing meridian theory and set the foundation for traditional acupuncture today.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659449 | PMC |
http://dx.doi.org/10.1089/acu.2024.0056 | DOI Listing |
Channels (Austin)
December 2025
Biorheology Research Laboratory, Faculty of Health, Griffith University, Gold Coast, Australia.
The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mechanosensory Piezo channels resulted in an explosion of research exploring the translation of mechanical cues into biochemical signals and dynamic cell morphology responses. One of the Piezo isoforms - Piezo1 - is integral in the erythrocyte (red blood cell; RBC) membrane.
View Article and Find Full Text PDFDrug Deliv Transl Res
August 2025
Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, 1 El Khartoum Square, PO Box 21521, Alexandria, Egypt.
Biopolymer-based composite films were primed by incorporating alginate and zein natural polymers using a solution-casting method and superbly assisted by eco-friendly prepared copper oxide nanoparticles (CuO NPs). The influence of the addition method of CaCl as a crosslinker and CuO NPs loading content (0.1, 0.
View Article and Find Full Text PDFJ Child Health Care
August 2025
Nursing College, Arab American University, Jenin city, Palestinian Territory.
In Occupied Palestinian territory (OPT), which is in a complex political situation and has limited access to resources, there is a critical need to deepen the understanding of how children with life-limiting and life-threatening illnesses are cared for. This study explores the experiences of parents caring for more than one child with a chronic or serious illness. A qualitative descriptive method was adopted, with data collected from several paediatric units in two OPT cities, Tulkarm and Ramallah.
View Article and Find Full Text PDFRSC Adv
August 2025
Chemistry Department, Faculty of Science, Beni-Suef University Beni-Suef 62514 Egypt.
Metadherin (MTDH/AEG-1/LYRIC) partners with Staphylococcal Nuclease Domain-Containing Protein 1 (SND1) to form an oncogenic hub that drives proliferation, survival and metastasis in many tumors. Interrupting this interaction dampens pivotal pathways-including NF-κB, PI3K/Akt and Wnt/β-catenin-and simultaneously promotes SND1 degradation, yielding broad antitumor effects. This review consolidates current knowledge of the MTDH-SND1 axis and highlights preclinical studies showing that genetic knock-out or pharmacologic blockade of the complex can sharply reduce primary growth and metastatic spread.
View Article and Find Full Text PDFJ Med Chem
August 2025
CNRS, INP, Inst Neurophysiopathol, Aix-Marseille Univ, 13005 Marseille, France.
Microtubule targeting agents (MTAs) constitute a vital category of tubulin-binding compounds deployed across anticancer therapies. Despite the array of MTA drugs developed by pharmaceutical entities, the quest for novel efficacious molecules continues unabated. We unveil an innovative in vitro MTA screening methodology employing nano-differential scanning fluorimetry (nanoDSF), presenting distinct advantages over known assays.
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