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We report the complete genome sequence of a penicillin-resistant subsp. isolate, AJ79, from a tonsillitis patient. The AJ79 genome consists of a chromosome (2,440,359 bp) and plasmid (9,887 bp), providing insights into the genetic basis of penicillin resistance in and its implications for treating tonsillitis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812309 | PMC |
http://dx.doi.org/10.1128/mra.01233-24 | DOI Listing |
Genetics
September 2025
Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Protein translation regulation is critical for cellular responses and development, yet how elongation stage disruptions shape these processes remains incompletely understood. Here, we identify a single amino acid substitution (P55Q) in the ribosomal protein RPL-36A of Caenorhabditis elegans that confers complete resistance to the elongation inhibitor cycloheximide (CHX). Heterozygous animals carrying both wild-type RPL-36A and RPL-36A(P55Q) develop normally but show intermediate CHX resistance, indicating a partial dominant effect.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Cancer Research Center of Marseille: Team DNA Damage and Genome Instability|CNRS, Inserm, Institut Paoli-Calmettes, Aix Marseille Université, Marseille 13009, France.
Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication, this ssDNA gap is filled in by one of the two lesion tolerance pathways: the error-prone Translesion Synthesis (TLS) or the error-free Homology Directed Gap Repair (HDGR). In the present work, we evidence a role for the RecBC complex distinct from its canonical function in homologous recombination at DNA double strand breaks.
View Article and Find Full Text PDFMol Biol Rep
September 2025
Department of Biosciences, Integral University, Kursi Road, Lucknow, 226026, India.
Background: The river ecosystems provide habitats and source of water for a number of species including humans. The uncontrolled accumulation of pollutants in the aquatic environment enhances the development of antibiotic-resistant bacteria and genes.
Methods: Water samples were collected seasonally from different sites of Gomti and Ganga River.
Planta
September 2025
Department of Biology, University of Naples Federico II, Via Cinthia 26, 80126, Naples, Italy.
The first complete plastid genome of the critically endangered species Valeriana trinervis was sequenced, assembled and compared with other published Valeriana plastomes. In this study, we assembled the plastid genome of the critically endangered, endemic species Valeriana trinervis (= Centranthus trinervis) and compare it with all published plastomes of Valeriana. We found not only differences in the inverted repeats boundaries, in the type and abundance of repeats, but also similarities in codon usage and microsatellite numbers.
View Article and Find Full Text PDFCurr Microbiol
September 2025
Department of Integrative Biotechnology, Sungkyunkwan University, Natural Science Campus, 2066 Seobu-ro, Jangan-Gu, Suwon-Si, Gyeonggi-Do, 16419, Republic of Korea.
A novel bacterial strain, SM-13 was isolated from the rhizospheric soil of Epipremnum aureum (Jade Pothos) sampled in Suwon, Republic of Korea. The isolate was Gram-stain-negative, aerobic, motile, rod-shaped, cream-coloured, oxidase- and catalase-positive. Strain SM-13 grew at the range of 15-37 °C (optimum, 25 °C), at pH 6.
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