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Aberrant right gastric veins (ARGV) represent rare anatomical variations that can result in hepatic pseudolesions, mimicking malignancies due to their atypical drainage directly into the liver parenchyma. This case highlights a 44-year-old woman initially presenting with a breast mass incidentally found to have an ARGV-related pseudolesion in hepatic segment IVa. ARGV is clinically significant as it can alter hepatic blood flow dynamics, leading to hyperdense or hypodense regions on imaging. Recognizing these pseudolesions is essential to avoid misdiagnosis, unnecessary procedures, and to distinguish them from true hepatic lesions. This case emphasizes the importance of advanced imaging modalities in diagnosing such anomalies, ensuring accurate patient management.
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http://dx.doi.org/10.1016/j.radcr.2024.11.022 | DOI Listing |
World J Hepatol
August 2025
Department of General Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou 730050, Gansu Province, China.
Background: A complete replacement left hepatic artery (LHA) solely originating from the left gastric artery (LGA), with no supply from the hepatic artery proper, is exceptionally rare. This variant places entire left lobe perfusion on the LGA. Literature review confirms no prior reports of such an isolated LHA replacement pattern in surgical/radiological publications.
View Article and Find Full Text PDFFront Immunol
September 2025
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with limited responses to immune checkpoint blockade (ICB) therapies in most patients. Increasing evidence indicates that the tumor immune microenvironment (TIME) plays a crucial role in immunotherapy outcomes. Among various metabolic abnormalities in the TIME, dysregulated lipid metabolism has emerged as a critical determinant of immune cell fate, differentiation, and function.
View Article and Find Full Text PDFNat Commun
August 2025
Division of Infectious Diseases at Brigham & Women's Hospital, and Department of Microbiology at Harvard Medical School, Boston, MA, USA.
Outbreaks of cholera are caused by the highly transmissive pathogen Vibrio cholerae. Infant mouse studies have elucidated many aspects of V. cholerae pathogenesis; however, the components of pathogenesis that feed-forward to promote transmission have remained enigmatic because animal models routinely bypass the mechanisms of inter-animal transmission by directly inoculating cultured bacteria into the stomach.
View Article and Find Full Text PDFResearch (Wash D C)
August 2025
Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Diffuse-type gastric cancer (DGC) is an aggressive tumor type characterized by a dense extracellular matrix (ECM). Metabolic reprogramming, a key oncogenic factor driving tumor progression, is closely linked to ECM deposition, although the regulatory mechanisms remain poorly understood. In this study, we integrated single-cell sequencing, proteomics, metabolomics, and large-scale clinical data to identify the metabolic signature of DGC.
View Article and Find Full Text PDFBJR Case Rep
July 2025
Faculty of Medicine, Department of Radiology, Koc University, Istanbul, 34010, Turkey.
Third inflow refers to the additional blood supply to the liver from a third source, apart from its dual blood supply. Aberrant right and left gastric veins, Sappey and Barlow veins, and the parabiliary venous system are considered the most significant examples of third inflow. Clinically, the third inflow is important due to its association with hepatic pseudolesions and its role in increasing surgical complication risks in hepatobiliary and gastric procedures.
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