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Background: Emergency department (ED) overcrowding is an important problem in many countries. Accurate predictions of ED patient arrivals can help management to better allocate staff and medical resources. In this study, we investigate the use of calendar and meteorological predictors, as well as feature-engineered variables, to predict daily patient arrivals using datasets from eleven different EDs across three countries.
Methods: Six machine learning (ML) algorithms were tested on forecasting horizons of 7 and 45 days. Three of them - Light Gradient Boosting Machine (LightGBM), Support Vector Machine with Radial Basis Function (SVM-RBF), and Neural Network Autoregression (NNAR) - were never before reported for predicting ED patient arrivals. Algorithms' hyperparameters were tuned through a grid-search with cross-validation. Prediction performance was assessed using fivefold cross-validation and four performance metrics.
Results: The eXtreme Gradient Boosting (XGBoost) was the best-performing model on both prediction horizons, also outperforming results reported in past studies on ED arrival prediction. XGBoost and NNAR achieved the best performance in nine out of the eleven analyzed datasets, with MAPE values ranging from 5.03% to 14.1%. Feature engineering (FE) improved the performance of the ML algorithms.
Conclusion: Accuracy in predicting ED arrivals, achieved through the FE approach, is key for managing human and material resources, as well as reducing patient waiting times and lengths of stay.
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http://dx.doi.org/10.1186/s12911-024-02788-6 | DOI Listing |
Alzheimers Res Ther
September 2025
Department of Neurology, Saarland University, Kirrberger Straße, 66421, Homburg/Saar, Germany.
Background: Alzheimer's disease (AD) patients and animal models exhibit an altered gut microbiome that is associated with pathological changes in the brain. Intestinal miRNA enters bacteria and regulates bacterial metabolism and proliferation. This study aimed to investigate whether the manipulation of miRNA could alter the gut microbiome and AD pathologies.
View Article and Find Full Text PDFBr J Cancer
September 2025
Institute of Life Sciences, Bhubaneswar, Odisha, India.
Background: Docetaxel is the most common chemotherapy regimen for several neoplasms, including advanced OSCC (Oral Squamous Cell Carcinoma). Unfortunately, chemoresistance leads to relapse and adverse disease outcomes.
Methods: We performed CRISPR-based kinome screening to identify potential players of Docetaxel resistance.
Am J Emerg Med
September 2025
University of South Carolina School of Medicine - Greenville, Greenville, SC, USA.
Total laryngectomy (TLE) results in the permanent separation of the respiratory and digestive tracts, requiring all airway interventions to occur exclusively via a neck stoma. Although airway obstruction in post-laryngectomy patients is uncommon, it can rapidly become fatal without prompt recognition and understanding of the altered anatomy. Here, we report the case of a patient with a recent TLE for squamous cell carcinoma, who presented to a rural Emergency Department (ED) in acute respiratory distress.
View Article and Find Full Text PDFAm J Emerg Med
September 2025
University of Toronto, Rotman School of Management, Canada.
Study Objective: Accurately predicting which Emergency Department (ED) patients are at high risk of leaving without being seen (LWBS) could enable targeted interventions aimed at reducing LWBS rates. Machine Learning (ML) models that dynamically update these risk predictions as patients experience more time waiting were developed and validated, in order to improve the prediction accuracy and correctly identify more patients who LWBS.
Methods: The study was deemed quality improvement by the institutional review board, and collected all patient visits to the ED of a large academic medical campus over 24 months.
JMIR Hum Factors
September 2025
Media Psychology Lab, Department of Communication Science, KU Leuven, Leuven, Belgium.
Background: Out-of-hospital cardiac arrests (OHCAs) are a leading cause of death worldwide, yet first responder apps can significantly improve outcomes by mobilizing citizens to perform cardiopulmonary resuscitation before professional help arrives. Despite their importance, limited research has examined the psychological and behavioral factors that influence individuals' willingness to adopt these apps.
Objective: Given that first responder app use involves elements of both technology adoption and preventive health behavior, it is essential to examine this behavior from multiple theoretical perspectives.