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http://dx.doi.org/10.1097/LVT.0000000000000558 | DOI Listing |
Physiol Rep
September 2025
Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
We evaluated the systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from whole-body, passive heating in young and older adults. Supine mean arterial pressure (MAP), cardiac output (Q; acetylene washin), systemic vascular conductance (SVC), heart rate (HR), and stroke volume (SV) were evaluated in 16 young (8F, 18-29 years) and nine older (6F, 61-73 years) adults at normothermic baseline and for 60-min passive heating and 120-min normothermic recovery. Externally applied neck pressure was used to evaluate HR, brachial vascular conductance, and MAP responses to carotid baroreceptor unloading.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
September 2025
Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada; Division of Thoracic Surgery, Department of Surgery, Universi
Objectives: To report the impact of ex vivo lung perfusion (EVLP) on lung transplantation practices and clinical outcomes. This study presents the largest single-centre EVLP experience to date, highlighting how EVLP has transformed clinical lung transplantation with expansion of donor access, program growth, and the safe use of extended criteria donor lungs.
Methods: We conducted a retrospective analysis of 1,000 consecutive EVLP procedures performed between 2008 and 2024 at University Health Network's Toronto General Hospital.
Chirurgia (Bucur)
August 2025
Ischemia time is a well-established determinant of liver transplant outcomes. Patient survival is substantially affected by prolonged warm (WIT) and cold ischemia time (CIT) of the graft during liver transplant. One component that may be a contributing factor to both WIT and CIT is back bench time (BBT).
View Article and Find Full Text PDFHepatobiliary Surg Nutr
August 2025
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Background And Objective: Hemadsorption, a therapeutic modality traditionally used to mitigate cytokine storm in critically ill patients and is now being tested in other medical fields including organ transplantation, especially for organs from extended criteria donors. Such organs are susceptible to ischemia-reperfusion injury (IRI) during transplantation, which is known to release a cascade of innate immune mediators including damage-associated molecular patterns (DAMPs) and cytokines during reperfusion and ultimately leading to graft dysfunction based on the metabolic injury. To address this challenge, early studies have integrated hemadsorption filters into organ perfusion circuits, such as normothermic regional perfusion (NRP) in donors and machine perfusion (MP) of grafts, with the aim to reduce inflammation and improve organ viability.
View Article and Find Full Text PDFWorld J Transplant
September 2025
Roger Williams Institute of Liver Studies, King's College London, London SE5 9NT, United Kingdom.
Paediatric liver transplantation (PLT) is a life-saving procedure for children with advanced liver disease or hepatoblastoma. The number of available grafts is limited in relation to the number of children on PLT waiting list. This graft shortage has led transplant societies and healthcare organizations to explore ways to investigate possible options and expand the donor pool.
View Article and Find Full Text PDF