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http://dx.doi.org/10.1002/wjo2.210 | DOI Listing |
Arch Toxicol
September 2025
Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Glyphosate, a widely used herbicide, has raised concerns regarding its impact on human health and the environment due to its widespread and excessive use. Adverse effects on the immune system have been reported. In this study, 26 vineyard workers in Veneto vineyards were examined before and after glyphosate applications to investigate possible immune parameter changes.
View Article and Find Full Text PDFFASEB J
September 2025
Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Severe burns are a major global health concern, and are associated with long-term physical and psychological impairments, multi-organ dysfunction, and substantial morbidity and mortality. While burn injuries in adults trigger systemic immuno-metabolic alterations-characterized by white adipose tissue browning, elevated resting energy expenditure, widespread catabolism, and inflammation-these adaptive responses are considerably impaired in older adults, with molecular mechanisms behind these differences remaining largely unclear. As a key regulator of systemic metabolism, investigating the pathological role of adipose tissue (AT) postburn may reveal novel targets that could potentially improve patient outcomes.
View Article and Find Full Text PDFJ Toxicol Environ Health A
September 2025
Department of Ecology and Conservation, Natural Sciences Institute, Federal University of Lavras, Lavras, MG, Brazil.
Flumioxazin-based herbicides are frequently used in agriculture to control broadleaf weeds attributed to their high efficacy, rapid action, and residual soil activity, making these compounds a preferred choice over other herbicides in pre-emergence weed control. Due to their beneficial properties, use of these herbicides has significantly increased in recent years, raising concerns regarding potential environmental risks. This study aimed to examine the effects of a commercial flumioxazin-based formulation on different plant models.
View Article and Find Full Text PDFJ Virol
September 2025
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Feline infectious peritonitis virus (FIPV) can cause an immune-mediated disease that is fatal to felines, but there is a lack of clinically effective protection conferred by vaccines. The methyltransferase (MTase) activity of the coronavirus nonstructural proteins nsp14 and nsp16 affects virulence, but there are no studies on the effect of nsp14 and nsp16 mutations affecting enzyme activity on the virulence of FIPV. In this study, we successfully rescued two mutant strains based on the previous infectious clone QS-79, named FIPV QS-79 dnsp14 and dnsp16, by mutating the MTase active sites of nsp14 (N415) and nsp16 (D129).
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